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Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)

Editor-in-Chief

ISSN (Print): 1871-5222
ISSN (Online): 1875-6115

IL-17 and its Receptor Complex as Therapeutic Targets in Arthritis

Author(s): Myew-Ling Toh and Pierre Miossec

Volume 8, Issue 3, 2008

Page: [247 - 251] Pages: 5

DOI: 10.2174/187152208785748331

Price: $65

Abstract

In addition to TNF and IL-1, IL-17 derived from Th17 cells is a leading cytokine target and has an established key role in adaptive and autoimmune disease such as rheumatoid arthritis (RA). A recent explosion in the literature in the last few years has lead to a renewal of interest in IL-17 as a key causative cytokine implicated in autoimmunity. This review will focus on IL-17 and its receptor as emerging therapeutic targets in RA.

Keywords: IL-17, Arthritis, TNF, cytokine, autoimmune disease, autoimmunity, therapeutic targets


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