Abstract
We developed a method that uses flow through voltammetric sensor to quantitatively determine thiazolidine-2, 4-diones (TZDs) derivatives which are pioglitazone, rosiglitazone and troglitazone. The method uses a gold electrode. The dynamic range for determining thiazolidine-2, 4-diones (TZDs) is extended by more than two orders of magnitude. The quantification limits are 0.10, 23, 15, 0.005 ng for thiazolidine-2, 4-dione, pioglitazone, rosiglitazone and troglitazone, respectively. The method can be applied to the quantitatively determining pioglitazone and rosiglitazone in antidiabetic drugs. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable.
Keywords: Voltammetric sensor, thiazolidine-2, 4-diones (TZDs), antidiabetic drugs.
Graphical Abstract
Current Pharmaceutical Analysis
Title:Simultaneous Determination of Antidiabetic Thiazolidinediones Using Flow Through Voltammetric Sensor
Volume: 10 Issue: 4
Author(s): Lai-Hao Wang and Yan-Lin Song
Affiliation:
Keywords: Voltammetric sensor, thiazolidine-2, 4-diones (TZDs), antidiabetic drugs.
Abstract: We developed a method that uses flow through voltammetric sensor to quantitatively determine thiazolidine-2, 4-diones (TZDs) derivatives which are pioglitazone, rosiglitazone and troglitazone. The method uses a gold electrode. The dynamic range for determining thiazolidine-2, 4-diones (TZDs) is extended by more than two orders of magnitude. The quantification limits are 0.10, 23, 15, 0.005 ng for thiazolidine-2, 4-dione, pioglitazone, rosiglitazone and troglitazone, respectively. The method can be applied to the quantitatively determining pioglitazone and rosiglitazone in antidiabetic drugs. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable.
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Cite this article as:
Wang Lai-Hao and Song Yan-Lin, Simultaneous Determination of Antidiabetic Thiazolidinediones Using Flow Through Voltammetric Sensor, Current Pharmaceutical Analysis 2014; 10 (4) . https://dx.doi.org/10.2174/1573412910666140818215811
DOI https://dx.doi.org/10.2174/1573412910666140818215811 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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