Abstract
Caffeine is the oldest consumed psychoactive drug, present in coffee, cocoa, tea, among other products. Several conventional methods are used to analyze caffeine, for example, chromatography and spectrometry, but these methods are expensive when compared to electroanalytical methods. The objective of this study is to study the feasible applicability of electrochemical techniques for quantification of caffeine in medications. Cyclic voltammetry was performed on the platinum electrode in 0.5 M H2SO4 and after that differential pulse voltammetry was performed to obtain the linear relation between caffeine concentration and current. A linear response in the electroanalytical approach exists from 38.05±3.02 to 192.39±1.04 ppm with a limit of detection of about 9.09±0.72 ppm. This sensor may represent a new analytical tool for caffeine analysis, based on existing literature.
Keywords: Caffeine, platinum sensor, cyclic voltammetry, drugs.
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Current Pharmaceutical Analysis
Title:Platinum Sensor for Quantifying Caffeine in Drug Formulations
Volume: 10 Issue: 4
Author(s): Danyelle Medeiros de Araujo, Chrystiane do Nascimento Brito, Severina Denise Sales de Oliveira, Djalma Ribeiro da Silva, Carlos A. Martinez-Huitle and Cícero Flavio Soares Aragao
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Keywords: Caffeine, platinum sensor, cyclic voltammetry, drugs.
Abstract: Caffeine is the oldest consumed psychoactive drug, present in coffee, cocoa, tea, among other products. Several conventional methods are used to analyze caffeine, for example, chromatography and spectrometry, but these methods are expensive when compared to electroanalytical methods. The objective of this study is to study the feasible applicability of electrochemical techniques for quantification of caffeine in medications. Cyclic voltammetry was performed on the platinum electrode in 0.5 M H2SO4 and after that differential pulse voltammetry was performed to obtain the linear relation between caffeine concentration and current. A linear response in the electroanalytical approach exists from 38.05±3.02 to 192.39±1.04 ppm with a limit of detection of about 9.09±0.72 ppm. This sensor may represent a new analytical tool for caffeine analysis, based on existing literature.
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Araujo Medeiros de Danyelle, Brito do Nascimento Chrystiane, de Oliveira Sales Severina Denise, Silva Ribeiro da Djalma, Martinez-Huitle A. Carlos and Aragao Flavio Soares Cícero, Platinum Sensor for Quantifying Caffeine in Drug Formulations, Current Pharmaceutical Analysis 2014; 10 (4) . https://dx.doi.org/10.2174/1573412910666140630191329
DOI https://dx.doi.org/10.2174/1573412910666140630191329 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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