Synthesis and Biochemical Evaluation of a Range of 4-(n-alkanesulfonate) benzyl Imidazole-Based Compounds as Inhibitors of Rat Testicular 17α-hydroxylase/17,20-lyase (P450_17α) in the Treatment of Hormone- Dependent Prostate Cancer

Title:Synthesis and Biochemical Evaluation of a Range of 4-(n-alkanesulfonate) benzyl Imidazole-Based Compounds as Inhibitors of Rat Testicular 17α-hydroxylase/17,20-lyase (P450_17α) in the Treatment of Hormone- Dependent Prostate Cancer

Volume: 11 Issue: 8

Author(s): Pallav S. Shah, Imran Shahid, Wai-Yee Lee, Caroline P. Owen and Sabbir Ahmed

Affiliation:

Keywords: 17α-hydroxylase/17, 17α-OHase, 20-lyase, Azole, Inhibitors Lyase.

Abstract: 17α-Hydroxylase/17,20-lyase is a target in the treatment of hormone-dependent prostate cancer. Here we report the results of a study into a range of alkanesulfonate derivatives of 4-hydroxybenzylimidazole which show the compounds to be good inhibitors with 5 [IC₅₀=1.11µM (17α-OHase) and IC₅₀=1.28µM (lyase)] being the most potent but weaker than ketoconazole.

Cite this article as:

Shah S. Pallav, Shahid Imran, Lee Wai-Yee, Owen P. Caroline and Ahmed Sabbir, Synthesis and Biochemical Evaluation of a Range of 4-(n-alkanesulfonate) benzyl Imidazole-Based Compounds as Inhibitors of Rat Testicular 17α-hydroxylase/17,20-lyase (P450_17α) in the Treatment of Hormone- Dependent Prostate Cancer, Letters in Drug Design & Discovery 2014; 11 (8) . https://dx.doi.org/10.2174/1570180811666131230235538

DOI https://dx.doi.org/10.2174/1570180811666131230235538	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X