Synthesis and Antitubercular Activities in Vitro of New p-Aminosalicylic Ester Imines

Title:Synthesis and Antitubercular Activities in Vitro of New p-Aminosalicylic Ester Imines

Volume: 11 Issue: 8

Author(s): Michael J. Hearn, Daniel J. Smaltz and Michael H. Cynamon

Affiliation:

Keywords: Antimycobacterial properties, Drug design, Inhibitory concentrations, Iron acquisition, Mycobacterium tuberculosis. Para- Aminosalicylic acid.

Abstract: In the present study, novel imines (5-16) of para-aminosalicylic esters were prepared in good yield and purity for the investigation of their antimycobacterial properties in vitro. The chemical structures of the compounds were determined by IR, ¹H-NMR, ¹³C-NMR, high resolution mass spectrometry and elemental analysis. Unlike para-aminosalicylic acid itself, these compounds are thermally stable and displayed activity in two models using pathogenic strains of Mycobacterium tuberculosis. Compound 5, bearing an ortho-hydroxybenzylidene unit, demonstrated promising activity in vitro and a range of cytotoxic and inhibitory properties that warrant further studies.

Cite this article as:

Hearn J. Michael, Smaltz J. Daniel and Cynamon H. Michael, Synthesis and Antitubercular Activities in Vitro of New p-Aminosalicylic Ester Imines, Letters in Drug Design & Discovery 2014; 11 (8) . https://dx.doi.org/10.2174/1570180811666140516233652

DOI https://dx.doi.org/10.2174/1570180811666140516233652	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X