Synthesis and Antimicrobial Activities of (4,5,6,7-Tetrahydro-1H-indazol- 2(3H)-yl)thiazole Derivatives

Title:Synthesis and Antimicrobial Activities of (4,5,6,7-Tetrahydro-1H-indazol- 2(3H)-yl)thiazole Derivatives

Volume: 11 Issue: 8

Author(s): Krzysztof Z. Laczkowski, Konrad Misiura, Anna Biernasiuk and Anna Malm

Affiliation:

Keywords: Antibacterial drugs, Antifungal drugs, Candida spp, Tetrahydroindazole, Thiazole.

Abstract: Synthesis, characterization and investigation of antimicrobial activities of ten novel tetrahydroindazolylthiazoles is presented. Their structures were determined using ¹H and ¹³C NMR, FAB(+)-MS and HRMS analyses. Among the derivatives, compound 3f shows strong antibacterial activity against S. aureus ATCC 43300, S. aureus ATCC 25923, and S. epidermidis ATCC 12228 with MIC 7.81 µg/ml, and good activity against S. aureus ATCC 6538 with MIC 31.25 µg/ml. Compounds 3a-e and 3j show good antifungal activity with MIC values ranging from 31.25 µg/ml to 250 µg/ml.

Cite this article as:

Laczkowski Z. Krzysztof, Misiura Konrad, Biernasiuk Anna and Malm Anna, Synthesis and Antimicrobial Activities of (4,5,6,7-Tetrahydro-1H-indazol- 2(3H)-yl)thiazole Derivatives, Letters in Drug Design & Discovery 2014; 11 (8) . https://dx.doi.org/10.2174/1570180811666140516233913