The Effects of Psychological Stress on Depression

Title:The Effects of Psychological Stress on Depression

Volume: 13 Issue: 4

Author(s): Longfei Yang, Yinghao Zhao, Yicun Wang, Lei Liu, Xingyi Zhang, Bingjin Li and Ranji Cui

Affiliation:

Keywords: Brain-derived neurotrophic factor, depression, glial cell-derived neurotrophic factor, hippocampus, nucleus accumbens, prefrontal cortex, psychological stress, ventral tegmental area.

Abstract: Major depressive disorder is a serious mental disorder that profoundly affects an individual's quality of life. Although the aetiologies underlying this disorder remain unclear, an increasing attention has been focused on the influence imposed by psychological stress over depression. Despite limited animal models of psychological stress, significant progress has been made as to be explicated in this review to elucidate the physiopathology underlying depression and to treat depressive symptoms. Therefore, we will review classical models along with new methods that will enrich our knowledge of this disorder.

Cite this article as:

Yang Longfei, Zhao Yinghao, Wang Yicun, Liu Lei, Zhang Xingyi, Li Bingjin and Cui Ranji, The Effects of Psychological Stress on Depression, Current Neuropharmacology 2015; 13 (4) . https://dx.doi.org/10.2174/1570159X1304150831150507