Synthesis and Anticonvulsant Activity of Some Non-Classical Dihydropyridine Like Structures

Title:Synthesis and Anticonvulsant Activity of Some Non-Classical Dihydropyridine Like Structures

Volume: 10 Issue: 9

Author(s): Mohammad Sharifzadeh, Hamid Reza khademi, Ali Almasirad, Zahra rezayan, Mohsen Rezayan Ghayahbashi and Mohsen Amini

Affiliation:

Keywords: Seizure, Anticonvulsant, Hexahydroquinoline derivative, 1, 4-dihydropyrimidine derivative, PTZ animal model, Synthesis.

Abstract: A series of dihydropyridine analogous was synthesized and evaluated for anticonvulsant activity using PTZ animal model. The main strategies are introducing a non-classical dihydropyridine like structure as anti-seizure agent. Some compounds showed significant anticonvulsant activity in comparison with the control group.

Cite this article as:

Sharifzadeh Mohammad, khademi Reza Hamid, Almasirad Ali, rezayan Zahra, Ghayahbashi Rezayan Mohsen and Amini Mohsen, Synthesis and Anticonvulsant Activity of Some Non-Classical Dihydropyridine Like Structures, Letters in Drug Design & Discovery 2013; 10 (9) . https://dx.doi.org/10.2174/15701808113109990015