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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

The Interaction Between FAK, MYCN, p53 and Mdm2 in Neuroblastoma

Author(s): Alicia M. Waters and Elizabeth A. Beierle

Volume 14, Issue 1, 2014

Page: [46 - 51] Pages: 6

DOI: 10.2174/18715206113136660331

Price: $65

Abstract

Neuroblastoma tumorigenesis and malignant transformation is driven by overexpression and dominance of cell survival pathways and a lack of normal cellular senescence or apoptosis. Therefore, manipulation of cell survival pathways may decrease the malignant potential of these tumors and provide avenues for the development of novel therapeutics. This review focuses on the individual protein tyrosine kinase, focal adhesion kinase (FAK) and its interaction with the transcription factors, MYCN, p53, and Mdm2, and how their interactions modulate the growth and malignancy of neuroblastomas.

Keywords: FAK, Mdm2, MYCN, neuroblastoma, p53.


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