Abstract
Thiazolidinones, synthesized from multicomponent reactions of 2-heteroarylmethylamine, arenealdehydes and mercaptoacetic acid, have been tested against six yeasts, namely Candida albicans, C. parapsilosis, C. guilliermondii, Cryptococcus laurentii, Trichosporon asahii and Rhodotorula spp. The activities were expressed as minimum inhibitory concentrations (MIC) and the minimum fungicidal concentrations (MFC). The most affected yeasts were Rhodotorula spp and T. asahii. The cytotoxicities of the thiazolidinones against the fibroblast 3T3/NIH cell line are also described. The antifungal results and the low cytotoxicity of the compounds in this work provide good guides for the further development of active compounds.
Keywords: Antifungal activity, cytotoxic activity, Rhodotorula, thiazolidinones.
Medicinal Chemistry
Title:Antifungal Activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone Derivatives
Volume: 10 Issue: 4
Author(s): Gabriela H. Marques, Alice Kunzler, Valeria D.O. Bareno, Bruna B. Drawanz, Hellen G. Mastelloto, Fabio R.M. Leite, Gustavo G. Nascimento, Patrícia S. Nascente, Geonir M. Siqueira and Wilson Cunico
Affiliation:
Keywords: Antifungal activity, cytotoxic activity, Rhodotorula, thiazolidinones.
Abstract: Thiazolidinones, synthesized from multicomponent reactions of 2-heteroarylmethylamine, arenealdehydes and mercaptoacetic acid, have been tested against six yeasts, namely Candida albicans, C. parapsilosis, C. guilliermondii, Cryptococcus laurentii, Trichosporon asahii and Rhodotorula spp. The activities were expressed as minimum inhibitory concentrations (MIC) and the minimum fungicidal concentrations (MFC). The most affected yeasts were Rhodotorula spp and T. asahii. The cytotoxicities of the thiazolidinones against the fibroblast 3T3/NIH cell line are also described. The antifungal results and the low cytotoxicity of the compounds in this work provide good guides for the further development of active compounds.
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Marques H. Gabriela, Kunzler Alice, Bareno D.O. Valeria, Drawanz B. Bruna, Mastelloto G. Hellen, Leite R.M. Fabio, Nascimento G. Gustavo, Nascente S. Patrícia, Siqueira M. Geonir and Cunico Wilson, Antifungal Activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone Derivatives, Medicinal Chemistry 2014; 10 (4) . https://dx.doi.org/10.2174/15734064113099990030
DOI https://dx.doi.org/10.2174/15734064113099990030 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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