Novel Multifunctional Anti-Alzheimer Drugs with Various CNS Neurotransmitter Targets and Neuroprotective Moieties

Title: Novel Multifunctional Anti-Alzheimer Drugs with Various CNS Neurotransmitter Targets and Neuroprotective Moieties

Volume: 4 Issue: 5

Author(s): Cornelis J. Van der Schyf, Silvia Mandel, Werner J. Geldenhuys, Tamar Amit, Yael Avramovich, Hailin Zheng, Mati Fridkin, Shunit Gal, Orly Weinreb, Orit Bar Am, Yotam Sagi and Moussa B.H. Youdim

Affiliation:

Keywords: NMDA receptor, Deferoxamine, reactive oxygen species, MAO-B inhibitor, Neuronal nitric oxide

Abstract: Traditionally, drug design programs are focused on optimizing the specificity of lead compounds against a carefully selected drug target. Disappointingly, this approach to discover a “magic bullet” drug has not met with the expected success for CNS disorders. Transcriptomics and proteomic profiling of neurodegenerative diseases have indicated that they are poly-etiological in origin and that the processes leading to neuronal death are multifactorial. An emerging concept is the design of drug ligands that modulate multiple drug targets identified for a particular disease. In this review we explore some examples of multifunctional drugs which may be useful in the treatment of neurodegenerative diseases, such as Alzheimers and Parkinsons disease.

Cite this article as:

Van der Schyf J. Cornelis, Mandel Silvia, Geldenhuys J. Werner, Amit Tamar, Avramovich Yael, Zheng Hailin, Fridkin Mati, Gal Shunit, Weinreb Orly, Am Bar Orit, Sagi Yotam and Youdim B.H. Moussa, Novel Multifunctional Anti-Alzheimer Drugs with Various CNS Neurotransmitter Targets and Neuroprotective Moieties, Current Alzheimer Research 2007; 4 (5) . https://dx.doi.org/10.2174/156720507783018226