Login Register Cart 0
Generic placeholder image

The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Thespesia populnea: An Ethnomedicinal, Phytochemical and Pharmacological Review

Author(s): Ashish Vishwakarma, Poonam Arora* and Mahaveer Dhobi*

Volume 12, Issue 2, 2022

Published on: 10 December, 2020

Article ID: e160921188996 Pages: 11

DOI: 10.2174/2210315510999201210142313

Price: $65

Abstract

Thespesia populnea, family Malvaceae, commonly known as paras pipal and Indian tulip tree, is widely distributed in coastal forests of India and south-eastern areas. The plant is medicinally used for the treatment of numerous diseases, including cutaneous infections, brain and liver disorders. The review summarizes all the information related to botanical characteristics, traditional uses, chemical components and biological activities of T. populnea, in order to exploit the therapeutic potential of this plant. The available information about T. populnea was collected through the online search on Web of Science, PubMed, Science Direct, Springer and Google Scholar. T. populnea is widely explored concerning its phytochemistry and biological activities. Amongst all phytoconstituents present in Thespesia, sesquiterpenes and phenolic compounds are major bioactive ingredients in the plant. Experimental studies show that these compounds exhibit a wide range of biological activities including anti-inflammatory, antidiabetic, analgesic, wound healing, anti-alzheimer, anti-ulcer and anti-psoriasis in in vitro and in vivo animal studies. To sum up, the plant, T. populnea, possesses high medicinal and social value, and deserves further investigation. T. populnea is a promising plant to be utilized in the development of pharmaceutical drug products. However, there is a lack of scientific studies to confirm its ethnopharmacological uses. In addition, further studies on the isolation of bioactive molecules and their pharmacological studies are recommended that could be of great significance towards the clinical application of this plant.

Keywords: Thespesia populnea, malvaceae, paras pipal, flavonoids, sesquiterpenes, anti-Alzheimer’s.

Graphical Abstract

[1]
Parthasarathy, R.; Ilavarasan, R.; Karrunakaran, C.M. Pharmacognosticalstudies on Thespesia populnea Bark. Res. J. Pharmacogn.Phytochem., 2009, 1(2), 128-131.
[2]
Phanse, M.A.; Patil, M.J.; Abbulu, K. Review on pharmacologicalstudies of Thespesia populnea Linn. Int. J. Pharm. Pharm. Sci., 2013, 5(3), 1-5.
[3]
Kirtikar, K.R. Basu.; B.D. Indian Medicinal Plants; Lalit MohanPublication: Allahabad, 1998, pp. 1924-1927.
[4]
Rao, B.; Jeevitha, K. Devarakonda. R; Heera B. Review of literature:Phytopharmacological studies on Thespesia populnea. J. Glob. Trends Pharm. Sci., 2018, 9(1), 4787-4792.
[5]
Pamnani, M.; Kumar, V.; Kaushal, K.; Sharma, A.K.; Mishra, R.C.; Soni, P.A. Critical review on paras-pipal (Thespesia populneaLinn)” an ayurvedic herb. J. Nat. Ayur. Med., 2018, 2(3)000130
[6]
Pratap, C.R.; Manju, S.; Vysakhi, M.V.; Shaji, P.K.; Achuthan, N.G. Antibacterial and antifungal activities of Thespesia populnealeaf extracts against human pathogens. Int. J. Pharm. Tech. Res., 2014, 6(1), 290-297.
[7]
Ilavarasan, R.; Vasudevan, M.; Anbazhagan, S.; Venkataraman, S.; Sridhar, S.K. Hepatoprotective activity of Thespesia populneabark extracts against carbon tetrachloride-induced liver toxicity inrats. Nat. Prod. Sci., 2003, 9(2), 83-86.
[8]
Kavimani, S.; Ilango, R.; Karpagam, S.; Suryaprabha, K.; Jaykar, B. Anti-steroidogenic activity of floral extract of Thespesia populneaCorr. in mouse ovary. Indian J. Exp. Biol., 1999, 37(12), 1241-1242.
[PMID: 10865891]
[9]
Ghosh, K.; Bhattacharya, T.K. Preliminary study on the anti-implantationactivity of compounds from the extracts of seeds of Thespesiapopulnea. Indian J. Pharmacol., 2004, 36(5), 288.
[10]
Vasudevan, M.; Gunnam, K.K.; Parle, M. Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract. J. Ethnopharmacol., 2007, 109(2), 264-270.
[http://dx.doi.org/10.1016/j.jep.2006.07.025] [PMID: 16949778]
[11]
Shrivastav, S.; Sindhu, R.; Kumar, S.; Kumar, P. Anti-psoriaticand phytochemical evaluation of Thespesia populnea bark extracts. Int. J. Pharm. Pharm. Sci., 2009, 1(sup 1)
[12]
Ilavarasan, R.; Vasudevan, M.; Anbazhagan, S.; Venkataraman, S. Antioxidant activity of Thespesia populnea bark extracts againstcarbon tetrachloride-induced liver injury in rats. J. Ethnopharmacol., 2003, 87(2-3), 227-230.
[http://dx.doi.org/10.1016/S0378-8741(03)00147-8] [PMID: 12860313]
[13]
Vasudevan, M.; Parle, M. Pharmacological actions of Thespesiapopulnea relevant to Alzheimer’s disease. Phytomedicine, 2006, 13(9-10), 677-687.
[http://dx.doi.org/10.1016/j.phymed.2006.01.007] [PMID: 16860552]
[14]
Parthasarathy, R.; Ilavarasan, R.; Karrunakaran, C.M. Antidiabeticactivity of Thespesia Populnea bark and leaf extract against streptozotocininduced diabetic rats. Int. J. Pharm. Tech. Res., 2009, 1(4), 1069-1072.
[15]
Gaikwad, S.B.; Mohan, D.G. Immunomodulatory activity ofmethanolic extract of Thespesia populnea leaves in wistar albinorats. Asian J. Pharm. Clin. Res., 2011, 4(4), 603-611.
[16]
Patil, P.H.; Patil, J.Y.; Mahale, J.N.; Patel, J.B.; Surana, S.J. Evaluationof antiulcer activity of the terpenoid fraction from the leavesof Thespesia populnea (L) (Malvaceae) in albino rats. Res. J. Pharm. Biol. Chem. Sci., 2010, 1(4), 495-513.
[17]
Vasudevan, M.; Parle, M. Memory-Enhancing Activity of Thespesiapopulnea. in Rats. Pharm. Biol., 2007, 45(4), 267-273.
[http://dx.doi.org/10.1080/13880200701214631]
[18]
Khadkutkar, D.K.; Kanthi, V.G.; Dudhamal, T.S. Antimicrobialactivity of Panchavalkal powder and ointment. Inter. J. Med.Plants Nat. Prod., 2015, 1(3), 9-15.
[19]
Ayurvedic Pharmacopoeia of India, 2006, 5(Part 1), 63-64.
[20]
Harborne, J.B. Indian medicinal plants. A compendium of 500 species. J. Pharm. Pharmacol., 1996, 46(11), 935.
[21]
Masila, V.M.; Midiwo, J.O.; Zhang, J.; Gisacho, B.M.; Munayi, R.; Omosa, L.K.; Wiggers, F.T.; Jacob, M.R.; Walker, L.A.; Muhammad, I. Anti-vancomycin-resistant Enterococcus faeciumand E. faecalis activities of (-)-gossypol and derivatives from Thespesiagarckeana. Nat. Prod. Commun., 2015, 10(4), 613-616.
[22]
Maroyi, A. Azanza garckeana fruit tree: phytochemistry, pharmacology,nutritional and primary healthcare applications as herbalmedicine. Res. J. Med. Plant, 2017, 11(4), 115-123.
[http://dx.doi.org/10.3923/rjmp.2017.115.123]
[23]
Kosalge, S.B.; Fursule, R.A. Investigation of in vitro anthelminticactivity of Thespesia lampas (Cav.). Asian J. Pharm. Clin. Res., 2009, 2(2), 69-71.
[24]
Chumbhale, D.S.; Upasani, C.D. Pharmacognostic standardizationof stems of Thespesia lampas (Cav.) Dalz & Gibs. Asian Pac. J. Trop. Biomed., 2012, 2(5), 357-363.
[http://dx.doi.org/10.1016/S2221-1691(12)60056-2] [PMID: 23569930]
[25]
Milbrodt, M.; Konig, W.A.; Hausent, B.M. 7-Hydroxy-2, 3, 5, 6-tetrahydro-3, 6, 9-trimethylnaphtho [1, 8-B, C] pyran-4, 8-dionefrom Thespesia populnea. Phytochemistry, 1997, 45(7), 1523-1525.
[http://dx.doi.org/10.1016/S0031-9422(97)00161-1]
[26]
King, T.J. De, Silva; L., B. Optically active gossypol from Thespesiapopulnea. Tetrahedron Lett., 1968, 9(3), 261-263.
[http://dx.doi.org/10.1016/S0040-4039(01)98741-6]
[27]
Puckhaber, L.S.; Stipanovic, R.D. Thespesenone and dehydrooxoperezinone-6-methyl ether, new sesquiterpene quinones from Thespesiapopulnea. J. Nat. Prod., 2004, 67(9), 1571-1573.
[http://dx.doi.org/10.1021/np049847p] [PMID: 15387662]
[28]
Waller, D.P.; Bunyapraphatsara, N.; Martin, A.; Vournazos, C.J.; Ahmed, M.S.; Soejarto, D.D.; Cordell, G.A.; Fong, H.H.; Russell, L.D.; Malone, J.P. Effect of (+)-gossypol on fertility in male hamsters. J. Androl., 1983, 4(4), 276-279.
[http://dx.doi.org/10.1002/j.1939-4640.1983.tb02367.x] [PMID: 6618998]
[29]
Boonsri, S.; Karalai, C.; Ponglimanont, C.; Chantrapromma, S.; Kanjana-Opas, A. Cytotoxic and antibacterial sesquiterpenes fromThespesia populnea. J. Nat. Prod., 2008, 71(7), 1173-1177.
[http://dx.doi.org/10.1021/np800055q] [PMID: 18553924]
[30]
Fun, H.K.; Boonsri, S.; Chantrapromma, S.; Boonnak, N.; Karalai, C. 3, 6, 9-Trimethyl-2, 3-dihydrobenzo [de] chromene-7, 8-dione. Acta Crystallogr. Sect. E Struct. Rep. Online, 2007, 63(5), 2127-2129.
[http://dx.doi.org/10.1107/S1600536807014547]
[31]
Shirwaikar, A.; Srinivasan, K.K. New flavonoids from the flowersof Thespesia populnea. Curr. Res. Med. Aromat. Plants, 1996, 18(2), 266-269.
[32]
Daniel, M. Medicinal plants-Chemistry and Properties Science publishers: Jersey, Saint Helier, 2006, p. 184;
[33]
Datta, S.C.; Murti, V.V.; Sharma, N.N.; Seshadri, T.R. Glycosidiccomponents of Thespesia populnea flowers. Indian J. Chem., 1973, 2013, 506-507.
[34]
Shirwaikar, A.; Kumar, A.V.; Krishnanand, B.R.; Sreenivasan, K.K. Chemical investigation and antihepatotoxic activity of Thespesiapopulnea. Int. J. Pharmacol., 1995, 33(4), 305-310.
[35]
Ilavarasan, R.; Mohideen, S.; Venkataraman, S. Analgesic and anti-inflammatory properties of Thespesia populnea leaf extracts. Nat. Prod. Res., 2012, 26(17), 1616-1620.
[http://dx.doi.org/10.1080/14786419.2011.574134] [PMID: 21916770]
[36]
Anju, R.; Shah, K. Significance of Sgot & Sgpt ratio (De Ritis Ratio)& Ggt levels in patients of liver cirrhosis with and without historyof alcoholism. Int J Res Med., 2017, 6(2), 1-3.
[37]
Parmar, K.M.; Shende, P.R.; Katare, N.; Dhobi, M.; Prasad, S.K. Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats. J. Pharm. Pharmacol., 2018, 70(10), 1389-1400.
[http://dx.doi.org/10.1111/jphp.12975] [PMID: 29984407]
[38]
Anandjiwala, S.; Bagul, M.S.; Srinivasa, H.; Kalola, J.; Rajani, M. Antioxidant activity of stem bark of Thespesia populnea Solandex Corr. J. Nat. Rem., 2007, 7(1), 135-141.
[39]
Sangeetha, R.; Vedasree, N. In vitro α-amylase inhibitory activityof the leaves of Thespesia populnea. ISRN Pharmacol., 2012, 2012
[http://dx.doi.org/10.5402/2012/515634] [PMID: 22550597]
[40]
Vasisht, K.; Dhobi, M.; Khullar, S.; Mandal, S.K.; Karan, M. Norneolignansfrom the roots of Clitoria ternatea L. Tetrahedron Lett., 2016, 57(16), 1758-1762.
[http://dx.doi.org/10.1016/j.tetlet.2016.03.024]
[41]
Kumar, D.; Dhobi, M. Screening antianxiety and antioxidant profileof stems and leaves of blue variety of Clitoria ternatea L. Indian J. Pharm. Sci., 2018, 79(6), 1022-1025.
[42]
Arora, P.; Ansari, S.H.; Anjum, V.; Mathur, R.; Ahmad, S. Investigationof anti-asthmatic potential of Kanakasava in ovalbumin-inducedbronchial asthma and airway inflammation in rats. J. Ethnopharmacol., 2017, 197, 242-249.
[http://dx.doi.org/10.1016/j.jep.2016.07.082] [PMID: 27502540]
[43]
Arora, P.; Ansari, S.H.; Najmi, A.K.; Anjum, V.; Ahmad, S. Investigationof anti-asthmatic potential of dried fruits of Vitisvinifera L. in animal model of bronchial asthma. Allergy Asthma Clin. Immunol., 2016, 12(1), 42.
[http://dx.doi.org/10.1186/s13223-016-0145-x] [PMID: 27536321]
[44]
Suvarna, M.Ch.; Sriya, P. Arshad, Md.; Pavan, K. A Review on phytochemical and pharmacological properties of Thespesia Populnea. J. Drug Deliv. Ther., 2018, 8(4), 1-4.
[http://dx.doi.org/10.22270/jddt.v8i4.1718]
[45]
Solomon, S. Murugananthan; Senthamilselvi, M.M. Anti-oxidantand anti-inflammatory activity of Thespesia populnea (flowers). Pharmacophore., 2015, 6(1), 53-59.
[46]
Azab, A.E.; Adwas, A.A.; Elsayed, A.S.; Quwaydir, F.A. Oxidativestress and antioxidant mechanisms in human body. J. ApplBiotechnology Bioeng., 2019, 6(6), 43-47.
[47]
Yuvaraj, P.; Subramoniam, A.; Louis, T.; Madhavachandran, V.; Antoney, M.; Narasu, M.L. Hepatoprotective properties of phenolicacids from Thespesia populnea Soland ex. Correa. Ann. Phytomed., 2012, 1(2), 74-87.
[48]
Parthasarathy, R.; Singh, A.; Bhowmik, D. In vitro antioxidant activityof bark and leaf of Thespesia populnea. Res. J. Pharmacog.Phytochem., 2016, 8(1), 1-4.
[49]
Siju, E.N.; Rajalakshmi, G.R.; Vipin, V.S.; Jolly, S. antioxidant activityof Thespesia populnea Linn fruits. Int. J. Pharm. Life Sci., 2004, 5(1), 3213-3216.
[50]
Patil, P.S.; Argade, P.D.; Ghule, R.S.; Venkatnarayanan, R.; Shinde, P.R. Protective effects of Thespesia populnea (L.) Sol ex.Correa in inflammatory, nociceptive and arthritic conditions on experimentalanimals. Br. J. Pharm. Res., 2012, 2(4), 215-227.
[http://dx.doi.org/10.9734/BJPR/2012/1774]
[51]
Shirwaikar, A.; Devi, S.; Siju, E.N. Anti-Inflammatory activity ofThespesia populnea fruits by membrane stabilization. Int. J. Pharm. Tech. Res., 2011, 3(4), 2060-2063.
[52]
Shah, A.S.; Alagawadi, K.R. Anti-inflammatory, analgesic and antipyreticproperties of Thespesia populnea Soland ex. Correa seedextracts and its fractions in animal models. J. Ethnopharmacol., 2011, 137(3), 1504-1509.
[http://dx.doi.org/10.1016/j.jep.2011.08.038] [PMID: 21893182]
[53]
Vishal, V.; Ganesh, S.N.; Mukesh, G.; Ranjan, B. A review onsome plants having anti-inflammatory activity. J. Phytopharmacology, 2014, 3(3), 214-221.
[54]
Solomon, S.; Muruganantham, N.; Senthamilselvi, M.M. Antimicrobialactivity of ethanolic crude extracts of Thespesia populneaFlowers. J. Pharm. Res. Int., 2015, 7(3), 176-182.
[http://dx.doi.org/10.9734/BJPR/2015/17307]
[55]
Senthil-Rajan, D.; Rajkumar, M.; Srinivasan, R.; Kumarappan, C.; Arunkumar, K.; Senthilkumar, K.L.; Srikanth, M.V. Investigationon antimicrobial activity of root extracts of Thespesia populneaLinn. Trop. Biomed., 2013, 30(4), 570-578.
[PMID: 24522124]
[56]
Lynch, I.; Dawson, K.A.; Linse, S. Detecting cryptic epitopes createdby nanoparticles. Sci. STKE, 2006, 2006(327), pe14.
[PMID: 16552091]
[57]
Gowsalya, V. Synthesis, characterization of ZnO nanoparticlesfrom Thespesia populea. Indian J. Appl. Res., 2017, 7(10), 287-296.
[58]
Hiteksha, S.P.; Mamta, B.S. Thespesia populnea Linn. A review. Int. J. Pharmacognosy., 2017, 4(1), 1-05.
[59]
Arora, P.; Ansari, S.H. Quality standard parameters of an anti-asthmatic ayurvedic formulation Kanakasava. Int. J. PharmacogPhytochem Res., 2014, 6(4), 983-987.
[60]
Nagappa, A.N.; Cheriyan, B. Wound healing activity of the aqueousextract of Thespesia populnea fruit. Fitoterapia, 2001, 72(5), 503-506.
[http://dx.doi.org/10.1016/S0367-326X(01)00275-1] [PMID: 11429243]
[61]
Chumbhale, D.S.; Pawase, A.A; Chaudhari, S.R; Upasani, C.D. Phytochemical, pharmacological and phytopharmaceutics aspects of thespesia populnea (Linn.) Soland.: A review. Invent. Impact Ethnopharmacol., 2010, 1(2) pep/155/21..
[62]
Dhingra, D.; Parle, M.; Kulkarni, S.K. Memory enhancing activityof Glycyrrhiza glabra in mice. J. Ethnopharmacol., 2004, 91(2-3), 361-365.
[http://dx.doi.org/10.1016/j.jep.2004.01.016] [PMID: 15120462]
[63]
Dhingra, D.; Parle, M.; Kulkarni, S.K. Genetic basis ofAlzheimer’s disease. Indian J. Pharm. Sci., 2005, 67(4), 409.
[64]
Anjum, V.; Arora, P.; Ansari, S.H.; Najmi, A.K.; Ahmad, S. Antithrombocytopenicand immunomodulatory potential of metabolically characterized aqueous extract of Carica papaya leaves. Pharm. Biol., 2017, 55(1), 2043-2056.
[http://dx.doi.org/10.1080/13880209.2017.1346690] [PMID: 28836477]
[65]
Dagytė, G.; Den Boer, J.A.; Trentani, A. The cholinergic systemand depression. Behav. Brain Res., 2011, 221(2), 574-582.
[http://dx.doi.org/10.1016/j.bbr.2010.02.023] [PMID: 20170685]
[66]
Zhang, d.; Zhang, S.; Wu, J. Chemical constituents of the bark of Thespesia populnea.. 2007, 18(9), 2156-2157.
[67]
Danilenko, D.M. Review paper: Preclinical models of psoriasis. Vet. Pathol., 2008, 45(4), 563-575.
[http://dx.doi.org/10.1354/vp.45-4-563] [PMID: 18587106]
[68]
Krueger, J.G.; Bowcock, A. Psoriasis pathophysiology: Currentconcepts of pathogenesis. Ann. Rheum. Dis., 2005, 64(Suppl. 2), 30-36.
[http://dx.doi.org/10.1136/ard.2004.031120] [PMID: 15708932]
[69]
Shekshavali, T.; Hugar, S. Antimicrobial activity of Thespesiapopulnea Soland. ex Correa bark extracts. Indian J. Nat. Prod. Resour., 2012, 3(1), 128-130.
[70]
Viswanatha, G.L.; Hanumanthappa, S.; Krishnadas, N.; Rangappa, S. Antidiarrheal effect of fractions from stem bark of Thespesiapopulnea in rodents: Possible antimotility and antisecretorymechanisms. Asian Pac. J. Trop. Med., 2011, 4(6), 451-456.
[http://dx.doi.org/10.1016/S1995-7645(11)60124-7] [PMID: 21771697]
[71]
Parthasarathy, R.; Ilavarasan, R.; Nandanwar, R. A study on preliminaryphytochemical and diuretic activity of bark of Thespesiapopulnea. Int. J. Pharm. Sci. Drug Res., 2010, 1(2), 72-77.
[72]
Kumar, A.S.; Venkateshwaran, K.; Vanitha, J.; Saravanan, V.S.; Ganesh, M.; Vasudevan, M.; Sivakumar, T. Synergistic activity of methanolic extract of Thespesia populnea (Malvaceae) flowerswith oxytetracycline. Bangladesh J. Pharmacol., 2009, 4(1), 13-16.
[73]
Muthukumar, S.; Veerappa, N.S. Phytochemical analysis in theroot and leaf of Thespesia populnea (Linn) Soland ex correa. J.Pharmacogn. Phytochem., 2018, 7(1), 414-417.

Rights & Permissions Print Cite
Article Metrics
19
© 2024 Bentham Science Publishers | Privacy Policy