Curcumin: A Natural Product for Diabetes and its Complications

Title:Curcumin: A Natural Product for Diabetes and its Complications

Volume: 15 Issue: 23

Author(s): Seyed Fazel Nabavi, Raman Thiagarajan, Luca Rastrelli, Maria Daglia, Eduardo Sobarzo-Sanchez, Heshmatollah Alinezhad and Seyed Mohammad Nabavi

Affiliation:

Keywords: Curcuma longa L., Curcumin, diabetes, Inflammation, Oxidative stress.

Abstract: Curcumin is the yellow-colored bioactive constituent of the perennial plant, Curcuma longa L., which possesses a wide range of physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective and anti-diabetic activities. Anti-diabetic activity of curcumin may be due to its potent ability to suppress oxidative stress and inflammation. Moreover, it shows a beneficial role on the diabetesinduced endothelial dysfunction and induces a down-regulation of nuclear factor-kappa B. Curcumin possesses a protective role against advanced glycation as well as collagen crosslinking and through this way, mitigates advanced glycation end products-induced complications of diabetes. Curcumin also reduces blood glucose, and the levels of glycosylated hemoglobin in diabetic rat through the regulation of polyol pathway. It also suppresses increased bone resorption through the inhibition of osteoclastogenesis and expression of the AP-1 transcription factors, c-fos and c-jun, in diabetic animals. Overall, scientific literature shows that curcumin possesses anti-diabetic effects and mitigates diabetes complications. Here we report a systematical discussion on the beneficial role of curcumin on diabetes and its complications with emphasis on its molecular mechanisms of actions.

Cite this article as:

Nabavi Fazel Seyed, Thiagarajan Raman, Rastrelli Luca, Daglia Maria, Sobarzo-Sanchez Eduardo, Alinezhad Heshmatollah and Nabavi Mohammad Seyed, Curcumin: A Natural Product for Diabetes and its Complications, Current Topics in Medicinal Chemistry 2015; 15 (23) . https://dx.doi.org/10.2174/1568026615666150619142519