Abstract
Ten artemisinin derivatives containing a piperazine at C-10 linked with ether or ester were designed and synthesized. All the derivatives have improved antiproliferative activity against cancer cell lines, including multidrug resistance (MDR) phenotypes. Compounds linked with ether are more effective than compounds linked with ester.
Keywords: Artemisinin, Synthesis, Leukemia, Growth inhibition, Structure-activity relationship
Letters in Drug Design & Discovery
Title: Design, Synthesis and Antiproliferative Activities of Artemisinin Derivatives Containing a Substituted Piperazine
Volume: 6 Issue: 8
Author(s): Xue-Lin Yang, Dan Liu, Wei Wang, Lei Qu, Yong-Kui Jing and Lin-Xiang Zhao
Affiliation:
Keywords: Artemisinin, Synthesis, Leukemia, Growth inhibition, Structure-activity relationship
Abstract: Ten artemisinin derivatives containing a piperazine at C-10 linked with ether or ester were designed and synthesized. All the derivatives have improved antiproliferative activity against cancer cell lines, including multidrug resistance (MDR) phenotypes. Compounds linked with ether are more effective than compounds linked with ester.
Export Options
About this article
Cite this article as:
Yang Xue-Lin, Liu Dan, Wang Wei, Qu Lei, Jing Yong-Kui and Zhao Lin-Xiang, Design, Synthesis and Antiproliferative Activities of Artemisinin Derivatives Containing a Substituted Piperazine, Letters in Drug Design & Discovery 2009; 6 (8) . https://dx.doi.org/10.2174/157018009789353446
DOI https://dx.doi.org/10.2174/157018009789353446 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Genetic Variants of IKZF1 Gene Linked with the Growing Risk of Childhood Acute Lymphoblastic Leukaemia
Current Molecular Medicine Genetics of Bladder Malignant Tumors in Childhood
Current Genomics Application of Chemistry-Based Functional Proteomics to Screening for Novel Drug Targets
Combinatorial Chemistry & High Throughput Screening A Phenotypic Screen for Small-Molecule Inhibitors of Constitutively Active Mutant Thrombopoietin Receptor Implicated in Myeloproliferative Neoplasms
Combinatorial Chemistry & High Throughput Screening Novel Mitotic Targets and Their Small-Molecule Inhibitors
Current Cancer Drug Targets Caspase-Independent Pathways of Programmed Cell Death: The Unraveling of New Targets of Cancer Therapy?
Current Cancer Drug Targets The Role of Mediterranean Diet, CoQ10 and Conjugated-Melatonin in Osteoporosis Primary Prevention and Therapy
Current Nutrition & Food Science Drug-Mediated Targeted Disruption of Multiple Protein Activities Through Functional Inhibition of the Hsp90 Chaperone Complex
Current Medicinal Chemistry S-Phase Kinase-Associated Protein-2 and Nuclear Factor-kappa Beta as Molecular Targets of Oral Burkitt’s Lymphoma Cell Induced by Quinolinone Derivate-Vesnarinone
Current Signal Transduction Therapy Polyploidy: The Link Between Senescence and Cancer
Current Pharmaceutical Design Potential Application of Gene Therapy to X-Linked Agammaglobulinemia
Current Gene Therapy Nucleic Acid-based Technologies in Therapy of Malignant Gliomas
Current Pharmaceutical Biotechnology A Descriptive Analysis of Post-Chemotherapy Development of Interstitial Lung Disease Using Spontaneous Reporting Data in Japan
Current Drug Safety Cytogenetic and Molecular Abnormalities in Myelodysplastic Syndrome
Current Molecular Medicine Reversal of ABC Drug Transporter-Mediated Multidrug Resistance in Cancer Cells: Evaluation of Current Strategies
Current Molecular Pharmacology Evaluation of Anticancer Activities of Gallic Acid and Tartaric Acid Vectorized on Iron Oxide Nanoparticles
Drug Delivery Letters DNA Methyltransferase-1 Inhibitors as Epigenetic Therapy for Cancer
Current Cancer Drug Targets Cerebrospinal Fluid Proteomes: From Neural Development to Neurodegenerative Diseases
Current Proteomics Marine Bromopyrrole Alkaloids: Synthesis and Diverse Medicinal Applications
Current Topics in Medicinal Chemistry The Origin of Lentivirus Research: Maedi-Visna Virus
Current HIV Research