Regulatory T-Cells: Immunomodulators in Health and Disease

Title: Regulatory T-Cells: Immunomodulators in Health and Disease

Volume: 6 Issue: 16

Author(s): Karen Scalzo, Magdalena Plebanski and Vasso Apostolopoulos

Affiliation:

Keywords: CD4+CD25+ regulatory cells, Tr1, Th3, immuno-modulatory drugs

Abstract: Regulation of immune responses is crucial in order to maintain immunological self-tolerance. This is maintained in the periphery by a number of cell types that have the capacity to control and regulate immune responses, thus preventing reactivity to self while monitoring appropriate, non-exuberant responses to non-self-antigens. The various mechanisms of regulation will be discussed in this review together with how this knowledge could be used to develop better drugs and treatments for various diseases.

Cite this article as:

Scalzo Karen, Plebanski Magdalena and Apostolopoulos Vasso, Regulatory T-Cells: Immunomodulators in Health and Disease, Current Topics in Medicinal Chemistry 2006; 6 (16) . https://dx.doi.org/10.2174/156802606778194262