H3 Receptor Antagonists: Pharmacophore Modeling and its Implications (Supplementry Material)

Title: H3 Receptor Antagonists: Pharmacophore Modeling and its Implications (Supplementry Material)

Volume: 6 Issue: 8

Author(s): A. B. Pramod, Sivasish Sindiri, M. Ravi Shashi Nayana, Santhosh Kumar Bairy, Ravi Shekar Ananthula, Ravikumar Muttineni, Madala Srividya and M. Kishore Kumar

Affiliation:

Keywords: Histamine, H3 receptor, Antagonist, Pharmacophore, Virtual Screening, HypoGen

Abstract: Quantitative 3-D pharmacophore model was generated using 30 chemically diverse H3 receptor antagonists and tested for its productiveness using a large test set. It had 2 hydrogen bond acceptor lipids, 1 positive ionizable and 1 hydrophobic feature. Pharmacophore analysis suggested the structural features required for increased H3 receptor activity.

Cite this article as:

Pramod B. A., Sindiri Sivasish, Nayana Ravi Shashi M., Bairy Kumar Santhosh, Ananthula Shekar Ravi, Muttineni Ravikumar, Srividya Madala and Kumar Kishore M., H3 Receptor Antagonists: Pharmacophore Modeling and its Implications (Supplementry Material), Letters in Drug Design & Discovery 2009; 6 (8) . https://dx.doi.org/10.2174/157018009789353428