Quantitative Structure Activity Relationship of Indole-Carbaldehyde Derivatives as Cannabinoid Receptor 2 Agonists

S.      Rituparna; S.   K.   Mahmood; M.      Ravikumar

doi:10.2174/157018009789353473

Abstract

QSAR has been established for 73 Indole-carbaldehyde derivatives acting as Cannabinoid receptor 2 agonists. The best model was developed using six descriptors from topological, thermodynamic, spatial and electrotopological class. The model had r2 value of 0.888, PRESS value of 7.825, XV r2 value of 0.841 and test set correlation value 0.881.

Keywords: Cannabinoid receptor 2, GPCR, QSAR, Indole-carbaldehyde derivatives, Agonists, Correlation coefficient (r2)

« Previous Next »

Rights & Permissions Print Cite

Letters in Drug Design & Discovery

Title: Quantitative Structure Activity Relationship of Indole-Carbaldehyde Derivatives as Cannabinoid Receptor 2 Agonists

Volume: 6 Issue: 8

Author(s): S. Rituparna, S. K. Mahmood and M. Ravikumar

Affiliation:

Keywords: Cannabinoid receptor 2, GPCR, QSAR, Indole-carbaldehyde derivatives, Agonists, Correlation coefficient (r2)

Abstract: QSAR has been established for 73 Indole-carbaldehyde derivatives acting as Cannabinoid receptor 2 agonists. The best model was developed using six descriptors from topological, thermodynamic, spatial and electrotopological class. The model had r2 value of 0.888, PRESS value of 7.825, XV r2 value of 0.841 and test set correlation value 0.881.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Rituparna S., Mahmood K. S. and Ravikumar M., Quantitative Structure Activity Relationship of Indole-Carbaldehyde Derivatives as Cannabinoid Receptor 2 Agonists, Letters in Drug Design & Discovery 2009; 6 (8) . https://dx.doi.org/10.2174/157018009789353473