Abstract
Tuberculosis (TB) remains one of the leading infectious killers in the world. New anti-TB drugs and more effective drug combinations are urgently needed, particularly given the increasing incidence of drug-resistant TB and HIV-TB co-infection. This review describes the available mouse models of TB and describes their utility in the evaluation of new TB drug candidates and in the evaluation of the efficacy of new TB drug combinations. Some of the most recent patents on promising TB drug-candidates are also mentioned here.
Keywords: Tuberculosis, drugs, mouse model
Recent Patents on Anti-Infective Drug Discovery
Title: Preclinical Study of New TB Drugs and Drug Combinations in Mouse Models
Volume: 3 Issue: 2
Author(s): Boris V. Nikonenko, Katherine A. Sacksteder, Sam Hundert, Leo Einck and Carol A. Nacy
Affiliation:
Keywords: Tuberculosis, drugs, mouse model
Abstract: Tuberculosis (TB) remains one of the leading infectious killers in the world. New anti-TB drugs and more effective drug combinations are urgently needed, particularly given the increasing incidence of drug-resistant TB and HIV-TB co-infection. This review describes the available mouse models of TB and describes their utility in the evaluation of new TB drug candidates and in the evaluation of the efficacy of new TB drug combinations. Some of the most recent patents on promising TB drug-candidates are also mentioned here.
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Cite this article as:
Nikonenko V. Boris, Sacksteder A. Katherine, Hundert Sam, Einck Leo and Nacy A. Carol, Preclinical Study of New TB Drugs and Drug Combinations in Mouse Models, Recent Patents on Anti-Infective Drug Discovery 2008; 3 (2) . https://dx.doi.org/10.2174/157489108784746579
DOI https://dx.doi.org/10.2174/157489108784746579 |
Print ISSN 1574-891X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4071 |
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