Abstract
Vitamin D is essential for maintaining a healthy mineral and bone metabolism. It stimulates calcium and phosphate absorption by the intestine, regulates bone metabolism, and negatively controls PTH secretion through the endocrine action of its active metabolite calcitriol. Vitamin D also possesses a variety of effects unrelated with mineral and bone metabolism, including the regulation of arterial blood pressure and the prevention of cardiovascular complications, modulation of immunological responses, regulation of insulin production and prevention against diabetes, protection against certain cancers, renoprotection, and other beneficial actions. This article provides an update review of the sources and pharmacological characteristics of natural vitamin D compounds, their most clinical uses, and their most important clinical results.
Keywords: Bone, calcitriol, calcium, calcifediol, cholecalciferol, ergocalciferol, parathyroid hormone, phosphate.
Current Vascular Pharmacology
Title:Pharmacologic Role of Vitamin D Natural Products
Volume: 12 Issue: 2
Author(s): Pablo Urena-Torres and Jean Claude Souberbielle
Affiliation:
Keywords: Bone, calcitriol, calcium, calcifediol, cholecalciferol, ergocalciferol, parathyroid hormone, phosphate.
Abstract: Vitamin D is essential for maintaining a healthy mineral and bone metabolism. It stimulates calcium and phosphate absorption by the intestine, regulates bone metabolism, and negatively controls PTH secretion through the endocrine action of its active metabolite calcitriol. Vitamin D also possesses a variety of effects unrelated with mineral and bone metabolism, including the regulation of arterial blood pressure and the prevention of cardiovascular complications, modulation of immunological responses, regulation of insulin production and prevention against diabetes, protection against certain cancers, renoprotection, and other beneficial actions. This article provides an update review of the sources and pharmacological characteristics of natural vitamin D compounds, their most clinical uses, and their most important clinical results.
Export Options
About this article
Cite this article as:
Urena-Torres Pablo and Souberbielle Claude Jean, Pharmacologic Role of Vitamin D Natural Products, Current Vascular Pharmacology 2014; 12 (2) . https://dx.doi.org/10.2174/15701611113119990020
DOI https://dx.doi.org/10.2174/15701611113119990020 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Bone Disease in Diabetes
Current Diabetes Reviews Pleiotropic Effects of Fenofibrate
Current Pharmaceutical Design Effects of Alpha-lipoic Acid Supplementation on Human Diabetic Nephropathy: A Systematic Review and Meta-analysis
Current Diabetes Reviews Clinical Utility of Microarrays: Current Status, Existing Challenges and Future Outlook
Current Genomics Critical Roles of Insulin-Induced Senescence in Diabetic Vasculopathy
Vascular Disease Prevention (Discontinued) Patent Selections
Recent Patents on Anti-Cancer Drug Discovery Heterogeneity of Pre-diabetes and Type 2 Diabetes: Implications for Prediction, Prevention and Treatment Responsiveness
Current Diabetes Reviews <i>Coccidioidomycosis</i> Resulting in a Prosthetic Joint Infection in an Immunocompetent Patient after a Total Hip Arthroplasty: A Case Report and Review of the Literature
Infectious Disorders - Drug Targets Development of Pyrazole Compounds as Antidiabetic Agent: A Review
Letters in Drug Design & Discovery Anti-obesity Effects of Some Plant Extracts in Rats Fed with High-Fat Diet
The Natural Products Journal RAGE in Diabetic Nephropathy
Current Molecular Medicine Potential Therapeutic Application of Chondroitin Sulfate/Dermatan Sulfate
Current Drug Discovery Technologies Dynamic Crosstalk between GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription and Human Disease
Current Signal Transduction Therapy Sodium Glucose Cotransporter-2 Inhibitor Treatment and the Risk of Diabetic Ketoacidosis in Denmark: A Retrospective Cohort Study of Five Years of Use
Current Drug Safety NAD(P)H Oxidase Activation: A Potential Target Mechanism for Diabetic Vascular Complications, Progressive β-Cell Dysfunction and Metabolic Syndrome
Current Drug Targets The Clinical Utility of Ambulatory Blood Pressure Monitoring (ABPM): A Review
Current Hypertension Reviews Protective Effect of CCR5 Delta-32 Allele Against HIV-1 in Mexican Women
Current HIV Research The Bioenergetics of Isolated Mitochondria from Different Animal Models for Diabetes
Current Diabetes Reviews Current Drug Nano-targeting Strategies for Improvement in the Diagnosis and Treatment of Prevalent Pathologies such as Cardiovascular and Renal Diseases
Current Drug Targets Flavonoids as Potential Therapeutic Agents for the Management of Diabetic Neuropathy
Current Pharmaceutical Design