New Heterocyclic Hydrazones in the Search for Antitubercular Agents: Synthesis and In Vitro Evaluations

Title: New Heterocyclic Hydrazones in the Search for Antitubercular Agents: Synthesis and In Vitro Evaluations

Volume: 3 Issue: 7

Author(s): A. Bijev

Affiliation:

Keywords: Carbohydrazides, Hydrazones, Pyrrole, Synthesis, Tuberculostatics

Abstract: Sixteen pyrrole containing hydrazones were synthesized from isoniazid (INH) or from 1H-1- pyrrolylcarbohydrazides. Nine products exhibited 92-100% inhibitory activity against Mycobacterium tuberculosis H37Rv at 6.25 μg/mL (Microplate Alamar Blue Assay). Two leads showed MICs 0.78 and > 0.1 μg/mL, SIs > 12.82 and > 100. "Drug likeness" was assessed by "Lipinski rule of five".

Cite this article as:

Bijev A., New Heterocyclic Hydrazones in the Search for Antitubercular Agents: Synthesis and In Vitro Evaluations, Letters in Drug Design & Discovery 2006; 3 (7) . https://dx.doi.org/10.2174/157018006778194790

DOI https://dx.doi.org/10.2174/157018006778194790	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X