Abstract
p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.
Keywords: p53, posttranscriptional regulation, RNA-binding proteins, translational regulation, mRNA decay
Current Molecular Medicine
Title: Posttranscriptional Regulation of p53 and its Targets by RNABinding Proteins
Volume: 8 Issue: 8
Author(s): Jin Zhang and Xinbin Chen
Affiliation:
Keywords: p53, posttranscriptional regulation, RNA-binding proteins, translational regulation, mRNA decay
Abstract: p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.
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Cite this article as:
Zhang Jin and Chen Xinbin, Posttranscriptional Regulation of p53 and its Targets by RNABinding Proteins, Current Molecular Medicine 2008; 8 (8) . https://dx.doi.org/10.2174/156652408786733748
DOI https://dx.doi.org/10.2174/156652408786733748 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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