Abstract
Apart from being the main energy reserves of the human body, triacylglycerols take part in metabolic processes that determine the rate of fatty acid oxidation, the plasma levels of free fatty acids, the biosynthesis of other lipid molecules and the metabolic fate of lipoproteins. Allosteric, hormonal, nutritional and transcriptional signals activate shortterm and long-term regulatory mechanisms that assure the storage of triacylglycerols (TAGs) under states of excess energy and their mobilization under conditions of metabolic stress. New enzymes and novel regulatory mechanisms, involved in triacylglycerol metabolism, have been recently discovered and new details on the fine tuning of their metabolic reactions are coming to light. This knowledge will help us understand the biochemical basis of several diseases for the pathogenesis of which triacylglycerols play a role.
Keywords: Triacylglycerols, metabolism, lipases, acyl-CoA, acyltransferases, lipolysis, lipogenesis, triacylglycerol rich lipoproteins
Current Drug Targets
Title: Triacylglycerol Metabolism
Volume: 10 Issue: 4
Author(s): Haralabos C. Karantonis, Tzortzis Nomikos and Constantinos A. Demopoulos
Affiliation:
Keywords: Triacylglycerols, metabolism, lipases, acyl-CoA, acyltransferases, lipolysis, lipogenesis, triacylglycerol rich lipoproteins
Abstract: Apart from being the main energy reserves of the human body, triacylglycerols take part in metabolic processes that determine the rate of fatty acid oxidation, the plasma levels of free fatty acids, the biosynthesis of other lipid molecules and the metabolic fate of lipoproteins. Allosteric, hormonal, nutritional and transcriptional signals activate shortterm and long-term regulatory mechanisms that assure the storage of triacylglycerols (TAGs) under states of excess energy and their mobilization under conditions of metabolic stress. New enzymes and novel regulatory mechanisms, involved in triacylglycerol metabolism, have been recently discovered and new details on the fine tuning of their metabolic reactions are coming to light. This knowledge will help us understand the biochemical basis of several diseases for the pathogenesis of which triacylglycerols play a role.
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Cite this article as:
Karantonis C. Haralabos, Nomikos Tzortzis and Demopoulos A. Constantinos, Triacylglycerol Metabolism, Current Drug Targets 2009; 10 (4) . https://dx.doi.org/10.2174/138945009787846443
DOI https://dx.doi.org/10.2174/138945009787846443 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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