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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Factors Affecting the Metabolite Productions in Endophytes: Biotechnological Approaches for Production of Metabolites

Author(s): Viridiana Morales-Sánchez, Maria Fe Andrés, Carmen Elisa Díaz and Azucena González-Coloma*

Volume 27, Issue 11, 2020

Page: [1855 - 1873] Pages: 19

DOI: 10.2174/0929867326666190626154421

Price: $65

Abstract

Since 1980, many species and different strains from endophytic genera of Phomopsis, Fusarium, Pestaliopsis and Aspergillus have been studied because of their ability to produce medicinal compounds found in their host plants. Some of these medicinal agents such as Taxol, Brefeldine A, Camptothecin and Podophyllotoxin are being produced in large-scale after an optimization process. However, the potential of fungal endophytes to produce host-like medicinal compounds remains largely unexplored.

Keywords: Endophytes, secondary metabolites, anticancer, drugs, biotechnology, medicinal compounds.

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