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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Developments in Thrombin-Activatable Fibrinolysis Inhibitor Research

Author(s): Pauline F. Marx, Chantal J.N. Verkleij, Mercedes Valls Seron and Joost C.M. Meijers

Volume 9, Issue 10, 2009

Page: [1165 - 1173] Pages: 9

DOI: 10.2174/138955709789055216

Price: $65

Abstract

Thrombin-activatable fibrinolysis inhibitor (TAFI) provides an important molecular link between the coagulation and fibrinolytic systems. In this review, recent major advances in TAFI research, including the elucidation of crystal structures, the development of small inhibitors and the role of TAFI in systems other than hemostasis, are described and discussed.

Keywords: TAFI, carboxypeptidase B, carboxypeptidase U, carboxypeptidase R, fibrinolysis, inflammation


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