Login Register Cart 0
Generic placeholder image

Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Natural Medicines as Gastro-protective Therapy in the Treatment of Peptic Ulcer: A Multifaceted Approach

Author(s): Pranjal Kumar Singh* and Trichy Siva Easwari

Volume 18, Issue 6, 2022

Published on: 21 April, 2022

Page: [559 - 573] Pages: 15

DOI: 10.2174/1573401318666220304150152

Price: $65

Abstract

Gastrointestinal (GI) disorders are the ailments of the digestive tract that affect its function, including digestion, absorption, and excretion. The dysfunction of the gastrointestinal tract may occur due to infections by bacteria, parasites, and viruses. Peptic ulcer disease is a gastrointestinal tract disorder of the stomach and duodenum associated with infection of Helicobacter pylori. Helicobacter pylori is regarded as the worldwide causative agent responsible for the etiology of peptic ulcer and gastric carcinoma. The existing drug therapies are good healers in this situation, but due to resistance problems and side effects of drugs, researchers have been working to find out some safe alternatives. Interestingly, the medicinal herbs have been used for treating several disorders, including peptic ulcers, and are considered an effective and safer alternative to existing drugs. They are also considered eco-friendly, easily available, safe, and less toxic than traditional treatment therapy. Combining herbal medicines with natural products has been shown effective in treating peptic ulcers. In this review, the medicinal plants used against H. pylori infection have been discussed. The mechanisms of herbal drugs in healing peptic ulcers involve inhibition of H+ K+ ATPase pump, reduction in gastric acid secretion, and protection of gastric mucosa that have also been elaborated in this review. The phytochemicals responsible for biological activity have been summarized in the present article. The combination of herbs and natural products in the form of the polyherbal formulation may also be helpful as an effective therapy for treating peptic ulcers. Medicinal plants may offer the researchers new chemical molecules to explore as future drugs or as biochemical agents to unravel the etiology of the disease.

Keywords: Proton pump, aloe vera, gastric emptying, acidity, natural products, peptic ulcer.

« Previous Next »
Graphical Abstract

[1]
Gupta M, Kapoor B, Gupta R, Singh N. Plants and phytochemicals for treatment of peptic ulcer: An overview. S Afr J Bot 2021; 138: 105-14.
[http://dx.doi.org/10.1016/j.sajb.2020.11.030]
[2]
WHO. Traditional medicine. 2003. Available from: apps.who.int/gb/archive/pdf_files/WHA56/ea5618.pdf (Accessed November 6, 2020)
[3]
Huang CY, Lai WY, Sun MF, et al. Prescription patterns of traditional Chinese medicine for peptic ulcer disease in Taiwan: A nationwide population-based study. J Ethnopharmacol 2015; 176: 311-20.
[http://dx.doi.org/10.1016/j.jep.2015.11.002] [PMID: 26549268]
[4]
Zhou B, Zhang W, Wu Y, et al. Improved efficacy of Panax notoginseng saponin loaded into BSP/alginate microspheres for the treatment of alcoholic gastric ulcers. Int J Pharm 2021; 596: 120218.
[http://dx.doi.org/10.1016/j.ijpharm.2021.120218] [PMID: 33493598]
[5]
Murray MT, Nowicki J. 207 - Peptic Ulcer-Duodenal and Gastric. St. Louis, MO: Churchill Livingstone 2020; pp. 1683-8.
[6]
Baker DA. Plants against Helicobacter pylori to combat resistance: An ethnopharmacological review. Biotechnol Rep (Amst) 2020; 26: e00470.
[http://dx.doi.org/10.1016/j.btre.2020.e00470] [PMID: 32477900]
[7]
Parasuraman S, Thing GS, Dhanaraj SA. Polyherbal formulation: Concept of Ayurveda. Pharmacogn Rev 2014; 8(16): 73-80.
[http://dx.doi.org/10.4103/0973-7847.134229] [PMID: 25125878]
[8]
Sen S, Chakraborty R. Herbs, gastrointestinal protection, and oxidative stress. In: Gracia-Sancho J, Salvadó JBT-GT, Eds. Gastrointestinal tissue: oxidative stress and dietary antioxidants cambridge, massachusetts. Academic Press 2017; pp. 259-74.
[9]
Rokaya MB, Uprety Y, Poudel RC, et al. Traditional uses of medicinal plants in gastrointestinal disorders in Nepal. J Ethnopharmacol 2014; 158(Pt A): 221-9.
[http://dx.doi.org/10.1016/j.jep.2014.10.014] [PMID: 25456430]
[10]
Gadekar R, Singour PK, Chaurasiya PK, Pawar RS, Patil UK. A potential of some medicinal plants as an antiulcer agents. Pharmacogn Rev 2010; 4(8): 136-46.
[http://dx.doi.org/10.4103/0973-7847.70906] [PMID: 22228953]
[11]
Karole S, Shrivastava S, Thomas S, et al. Polyherbal formulation concept for synergic action: A review. J Drug Deliv Ther 2019; 9: 453-66.
[http://dx.doi.org/10.22270/jddt.v9i1-s.2339]
[12]
Anand U, Jacobo-Herrera N, Altemimi A, Lakhssassi N. A comprehensive review on medicinal plants as antimicrobial therapeutics: Potential avenues of biocompatible drug discovery. Metabolites 2019; 9(11): 258.
[http://dx.doi.org/10.3390/metabo9110258] [PMID: 31683833]
[13]
Dias DA, Urban S, Roessner U. A historical overview of natural products in drug discovery. Metabolites 2012; 2(2): 303-36.
[http://dx.doi.org/10.3390/metabo2020303] [PMID: 24957513]
[14]
Kumar D, Kumar RR, Pathania S, Singh PK, Kalra S, Kumar B. Investigation of indole functionalized pyrazoles and oxadiazoles as anti-inflammatory agents: Synthesis, in-vivo, in-vitro and in-silico analysis. Bioorg Chem 2021; 114: 105068.
[http://dx.doi.org/10.1016/j.bioorg.2021.105068] [PMID: 34130110]
[15]
Khedr A. Antiulcer protective activity of gum Arabic (Acacia Senegal) in adult rats. Bull Natl Nutr Inst Arab Repub Egypt 2017; 49(1): 1-28.
[http://dx.doi.org/10.21608/bnni.2017.4245]
[16]
Bansal VK, Goel RK. Gastroprotective effect of Acacia nilotica young seedless pod extract: role of polyphenolic constituents. Asian Pac J Trop Med 2012; 5(7): 523-8.
[http://dx.doi.org/10.1016/S1995-7645(12)60092-3] [PMID: 22647813]
[17]
Malgave KK, Naikwade NS, Ladda PL, Shikalgar TS, Patil SS. Peptic ulcer healing activity of fruit pulp extract and seed oil of Adansonia digitata linn. Int J Pharm Sci Drug Res 2019; 11(5): 263-71.
[http://dx.doi.org/10.25004/IJPSDR.2019.110518]
[18]
Kamatou GP, Vermaak I, Viljoen AM. An updated review of Adansonia digitata: A commercially important African tree. S Afr J Bot 2011; 77(4): 908-19.
[http://dx.doi.org/10.1016/j.sajb.2011.08.010]
[19]
Bhar K, Mondal S, Suresh P. An eye catching review of Aegle marmelos L. (Golden Apple). Pharmacogn J 2019; 11(2): 20724.
[http://dx.doi.org/10.5530/pj.2019.11.34]
[20]
Batiha G. El-Saber, Beshbishy AM, Wasef GL, et al. Chemical constituents and pharmacological activities of garlic (Allium sativum L.): A review. Nutrients 2020; 12(3): 872.
[http://dx.doi.org/10.3390/nu12030872]
[21]
Kishore RN, Mangilal T, Anjaneyulu N, Abhinayani G, Sravya N. Investigation of anti-ulcer activity of alcoholic extract of bark of Albizia lebbeck on pyloric ligated rodent model. Int J Pharm Chem Biol Sci 2014; 3(3): 721-4.
[22]
Pujar M. Protective effect of bark extracts of Albizzia lebbeck Benth on peptic ulcers induced by physical and chemical agents in rodents microbial, plant and animal research. 1st ed. USA: Nova Science Publisher 2013; pp. 105-12.
[23]
Pandey M, Kosey S. Treatment and replenishment of G.I. tract with Combined Regimen Therapy (CRT) of allopathic (PPIs) and Ayurvedic (Aloe Vera) medicine in peptic ulcer disease to counteract relapse. J Gastrointest Dig Syst 2015; 5(272): 2.
[24]
Ye YN, So HL, Liu ESL, Shin VY, Cho CH. Effect of polysaccharides from Angelica sinensis on gastric ulcer healing. Life Sci 2003; 72(8): 925-32.
[http://dx.doi.org/10.1016/S0024-3205(02)02332-9] [PMID: 12493573]
[25]
Chao WW, Lin BF. Bioactivities of major constituents isolated from Angelica sinensis (Danggui). Chin Med 2011; 6: 29.
[http://dx.doi.org/10.1186/1749-8546-6-29] [PMID: 21851645]
[26]
Madhu C, Brainard PJ, Raj GP. Swapn and Rao ASS: Anti-ulcer activity of aqueous extract of Annona squamosa leaves on rats. Int J Pharm Sci Res 2012; 3(11): 4429-33.
[27]
Zahid M, Mujahid M, Singh PK, et al. Annona squamosa Linn. (custard apple): An aromatic medicinal plant fruit with immense nutraceutical and therapeutic potentials. Int J Pharm Sci Res 2018; 9(5): 1745-59.
[28]
Maity P, Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. The use of neem for controlling gastric hyperacidity and ulcer. Phytother Res 2009; 23(6): 747-55.
[http://dx.doi.org/10.1002/ptr.2721] [PMID: 19140119]
[29]
Sairam K, Rao CV, Babu MD, Goel RK. Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomedicine 2001; 8(6): 423-30.
[http://dx.doi.org/10.1078/S0944-7113(04)70060-4] [PMID: 11824516]
[30]
Jain P. Secondary metabolites for antiulcer activity. Nat Prod Res 2016; 30(6): 640-56.
[PMID: 25920371]
[31]
Kumar V, Bhat ZA, Kumar D, Khan NA, Chashoo IA, Ara I. Gastroprotective effect of leaf extracts of Basella alba var. alba against experimental gastric ulcers in rats. Rev Bras Farmacogn 2012; 22: 657-62.
[http://dx.doi.org/10.1590/S0102-695X2012005000032]
[32]
Singh R, Trilochana Y. Phytopharmacological evaluation of alcoholic extract of Berberis aristata leaf in the treatment of gastric ulcer. Int J Pharm Tech Res 2020; 13: 1-5.
[http://dx.doi.org/10.20902/IJPTR.2019.130101]
[33]
Chander V, Aswal JS, Dobhal R, Uniyal DP, Nautiyal V. A review on Pharmacological potential of Berberine; an active component of Himalayan Berberis aristata. J Phytopharmacol 2017; 6(1): 53-8.
[34]
Samyuktha K, Chinnala KM, Prathiba G, Rajendhar D, Reddy P. Evaluation of anti ulcer activity of ethanolic root extract of Beta vulgaris in rats. Int J Basic Clin Pharmacol 2017; 6: 359.
[http://dx.doi.org/10.18203/2319-2003.ijbcp20170330]
[35]
Rashed K, Butnariu M. Antimicrobial and antioxidant activities of Bauhinia racemosa lam. and chemical content. Iran J Pharm Res 2014; 13(3): 1073-80.
[PMID: 25276210]
[36]
Muniappan M, Sundararaj T. Antiinflammatory and antiulcer activities of Bambusa arundinacea. J Ethnopharmacol 2003; 88(2-3): 161-7.
[http://dx.doi.org/10.1016/S0378-8741(03)00183-1] [PMID: 12963137]
[37]
Rajkapoor B, Jayakar B, Kavimani S. Anti-ulcer effect of Bauhinia variegata linn. in rats. J Nat Rem 2003; 3: 215-7.
[38]
Sudheerkumar K, Seetaramswamy S, Babu KA, Kumar PK. Phyto pharmacognostical and isolation of chemical constituents from Bauhinia variegata leaf extract. J Pharmacogn Phytochem 2015; 4(1): 189-91.
[39]
Esmail Al-Snafi A. The chemical constituents and pharmacological effects of Calendula officinalis - a review. Indian J Pharm Sci Res 2015; 5(3): 172-85.
[40]
Colombo E, Sangiovanni E, D’Ambrosio M, et al. A bio-guided fractionation to assess the inhibitory activity of Calendula officinalis L. on the NF-κB driven transcription in human gastric epithelial cells. Evid Based Complement Alternat Med 2015; 2015: 727342.
[http://dx.doi.org/10.1155/2015/727342] [PMID: 26491463]
[41]
Kumar K, Kenganora M, Kumar S, Mythreyi R. Anti ulcer activity of ethanol extract of the stem bark of Careya arborea Roxb. Int Curr Pharm J 2013; 2(3): 78-82.
[http://dx.doi.org/10.3329/icpj.v2i3.13633]
[42]
Khaliq HA. Pharmacological studies on Careya arborea Roxb.; A review. J Phytopharmacol 2016; 5(1): 27-34.
[http://dx.doi.org/10.31254/phyto.2016.5106]
[43]
Oloyede HO, Adaja MC, Ajiboye TO, Salawu MO. Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. J Integr Med 2015; 13(2): 105-14.
[http://dx.doi.org/10.1016/S2095-4964(15)60160-1] [PMID: 25797641]
[44]
Vyas S, Khatri T, Vijay R, Dave P, Joshi H. Biochemical constituents in leaf of Carica papaya - Ethnomedicinal plant of kachchh region. Int Lett Nat Sci 2014; 12: 16-20.
[45]
Cheng CL, Guo JS, Luk J, Koo MWL. The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats. Life Sci 2004; 74(18): 2237-49.
[http://dx.doi.org/10.1016/j.lfs.2003.09.055] [PMID: 14987949]
[46]
Miller MJ, MacNaughton WK, Zhang X-J, et al. Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado. Am J Physiol Gastrointest Liver Physiol 2000; 279(1): G192-200.
[http://dx.doi.org/10.1152/ajpgi.2000.279.1.G192] [PMID: 10898763]
[47]
Cai Y, Evans FJ, Roberts MF, Phillipson JD, Zenk MH, Gleba YY. Polyphenolic compounds from Croton lechleri. Phytochemistry 1991; 30(6): 2033-40.
[http://dx.doi.org/10.1016/0031-9422(91)85063-6]
[48]
Akah PA, Orisakwe OE, Gamaniel KS, Shittu A. Evaluation of Nigerian traditional medicines: II. Effects of some Nigerian folk remedies on peptic ulcer. J Ethnopharmacol 1998; 62(2): 123-7.
[http://dx.doi.org/10.1016/S0378-8741(98)00060-9] [PMID: 9741884]
[49]
Ayo R, Amupitan J, Ndukwe GI, Audu OT. Some chemical constituents of the leaves of Cassia nigricans Vahl. Afr J Pure Appl Chem 2009; 3(11): 208-11.
[50]
Al-Mofleh IA, Alhaider AA, Mossa JS, Al-Sohaibani MO, Rafatullah S, Qureshi S. Protection of gastric mucosal damage by Coriandrum sativum L. pretreatment in Wistar albino rats. Environ Toxicol Pharmacol 2006; 22(1): 64-9.
[http://dx.doi.org/10.1016/j.etap.2005.12.002] [PMID: 21783688]
[51]
Yadav SK, Sah AK, Jha RK, Sah P, Shah DK. Turmeric (curcumin) remedies gastroprotective action. Pharmacogn Rev 2013; 7(13): 42-6.
[PMID: 23922455]
[52]
Hamza AH, Hussein RH, Alkhalf M. Medical science the prophylactic efficacy of cardamom elettaria gastric ulcer in a rat model. Medical Science 2019; 23(97): 395-403.
[53]
Jamal A, Javed K, Aslam M, Jafri MA. Gastroprotective effect of cardamom, Elettaria cardamomum Maton. fruits in rats. J Ethnopharmacol 2006; 103(2): 149-53.
[http://dx.doi.org/10.1016/j.jep.2005.07.016] [PMID: 16298093]
[54]
Bigoniya P, Rana AC. Pharmacological screening of Euphorbia neriifolia leaf hydro-alcoholic extract. J App Pharm 2010; 1(2): 1-17.
[http://dx.doi.org/10.21065/19204159.2.1]
[55]
Mali PY, Panchal SS. Euphorbia neriifolia L.: Review on botany, ethnomedicinal uses, phytochemistry and biological activities. Asian Pac J Trop Med 2017; 10(5): 430-8.
[http://dx.doi.org/10.1016/j.apjtm.2017.05.003] [PMID: 28647179]
[56]
Khazaei M, Salehi H. Protective effect of Falcaria vulgaris extract on ethanol induced gastric ulcer in rat. Iran J Pharmacol Ther 2006; 5(1): 43-6.
[57]
Choobkar N, Kakoolaki S, Mohammadi F. The biological effects of herbal medicine, Falcaria vulgaris: An article review. Iran J Aquat Anim Health 2017; 3(1): 74-83.
[58]
Marslin G, Vithalrao KP, Franklin G, Kalaichelvan V. Anti-ulcer (ulcer-preventive) activity of Ficus arnottiana Miq. (Moraceae) leaf methanolic extract. Am J Pharmacol Toxicol 2009; 4: 89-93.
[http://dx.doi.org/10.3844/ajptsp.2009.89.93]
[59]
Gregory M, Divya B, Mary RA, Viji MM, Kalaichelvan VK, Palanivel V. Anti-ulcer activity of Ficus religiosa leaf ethanolic extract. Asian Pac J Trop Biomed 2013; 3(7): 554-6.
[http://dx.doi.org/10.1016/S2221-1691(13)60112-4] [PMID: 23836366]
[60]
Chandrasekar SB, Bhanumathy M, Pawar AT, Somasundaram T. Phytopharmacology of Ficus religiosa. Pharmacogn Rev 2010; 4(8): 195-9.
[http://dx.doi.org/10.4103/0973-7847.70918] [PMID: 22228961]
[61]
Birdane FM, Cemek M, Birdane YO, Gülçin I, Büyükokuroğlu ME. Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats. World J Gastroenterol 2007; 13(4): 607-11.
[http://dx.doi.org/10.3748/wjg.v13.i4.607] [PMID: 17278229]
[62]
Rahnama M, Mehrabani D, Japoni S, Edjtehadi M, Saberi Firoozi M. The healing effect of licorice (Glycyrrhiza glabra) on Helicobacter pylori infected peptic ulcers. J Res Med Sci 2013; 18(6): 532-3.
[PMID: 24250708]
[63]
Jalilzadeh-Amin G, Najarnezhad V, Anassori E, Mostafavi M, Keshipour H. Antiulcer properties of Glycyrrhiza glabra L. extract on experimental models of gastric ulcer in mice. Iran J Pharm Res 2015; 14(4): 1163-70.
[PMID: 26664383]
[64]
Nugroho AE, Wijayanti A, Mutmainah M, Susilowati R, Rahmawati N. Gastroprotective effect of combination of hot water extracts of licorice (Glycyrrhiza glabra), pulasari stem bark (Alyxia reinwardtii), and sembung leaf (Blumea balsamifera) against aspirin-induced gastric ulcer model rats. J Evid Based Complementary Altern Med 2016; 21(4): NP77-84.
[http://dx.doi.org/10.1177/2156587216637469] [PMID: 26976086]
[65]
Srivastava S, Jaiswal J, Gautam H, Sharma S, Rao CV. Anti-ulcer activity of methanol extract of Hibiscus rosa sinensis leaves. Int J Pharm Pharm Sci 2013; 5: 829-30.
[66]
Venkatachalam D, Thavamani S, Vijayan S, Kr V, Krishniah M. Evaluation of anti-ulcer activity of ethanolic extracts of Indigofera tinctoria on albino rats. Int J Technol Glob 2018; 4: 2118-22.
[67]
Vijayakumar AR, Daniel EP, Ilavarasan R, Venkataraman S, Vijayakumar S. Ulcer protective activity of Jatropha gossypiifolia Linn. in wistar rats. Pharmacognosy Res 2016; 8(1): S61-6.
[PMID: 27114695]
[68]
Goli V, Macharla SP, Bhasker KV, Gowrishankar VNL, Bhaskar J, Dhanalakshmi Ch. Antiulcer activity of leaf extract of Lawsonia inermis in albino rats. Res J Pharm and Tech 2011; 4(9): 1436-8.
[69]
Maldonado-Celis ME, Yahia EM, Bedoya R, et al. Chemical composition of mango (Mangifera indica L.) fruit: Nutritional and phytochemical compounds. Front Plant Sci 2019; 10: 1073.
[http://dx.doi.org/10.3389/fpls.2019.01073] [PMID: 31681339]
[70]
Garabadu D, Singh S, Gautam T. Acetic acid-induced rat gastric ulcer Manilkara hexandra (Roxb.) dubard ameliorates acetic. J Diet Suppl 2021; 18(3): 278-92.
[PMID: 32449638]
[71]
Shah MB, Goswami SS, Santani DD. Effect of Manilkara hexandra (Roxb.) dubard against experimentally-induced gastric ulcers. Phytother Res 2004; 18(10): 814-8.
[http://dx.doi.org/10.1002/ptr.1565] [PMID: 15551386]
[72]
Singh S, Jha MK. A comprehensive pharmacognostic review: Manilkara hexandra (Roxb.) dubard. Int J Pharm Sci Res 2020; 11(8): 3645-52.
[73]
Vinothapooshan G, Sundar K. Anti-ulcer activity of Mimosa pudica leaves against gastric ulcer in rats. RJPBCS 2010; 1(4): 606-14.
[74]
Alam S, Asad M, Asdaq SM, Prasad VS. Antiulcer activity of methanolic extract of Momordica charantia L. in rats. J Ethnopharmacol 2009; 123(3): 464-9.
[http://dx.doi.org/10.1016/j.jep.2009.03.024] [PMID: 19501279]
[75]
Li QY, Liang H, Wang B, Zhao YY. Chemical constituents of Momordica charantia L. Yao Xue Xue Bao 2009; 44(9): 1014-8.
[PMID: 20055177]
[76]
Choudhary MK, Bodakhe SH, Gupta SK. Assessment of the antiulcer potential of Moringa oleifera root-bark extract in rats. J Acupunct Meridian Stud 2013; 6(4): 214-20.
[http://dx.doi.org/10.1016/j.jams.2013.07.003] [PMID: 23972244]
[77]
Swathi D, Prasad K. Antioxidant and antiulcer potential of ethanolic extract of bark of Myrica esculenta in pyloric ligation ulcer model. Int J Pharm Pharm Sci 2015; 7: 195-8.
[78]
Maity B, Banerjee D, Bandyopadhyay SK, Chattopadhyay S. Myristica malabarica heals stomach ulceration by increasing prostaglandin synthesis and angiogenesis. Planta Med 2008; 74(15): 1774-8.
[http://dx.doi.org/10.1055/s-0028-1088336] [PMID: 19016406]
[79]
Sumbul S, Ahmad MA, Asif M, Saud I, Akhtar M. Evaluation of Myrtus communis Linn. berries (common myrtle) in experimental ulcer models in rats. Hum Exp Toxicol 2010; 29(11): 935-44.
[http://dx.doi.org/10.1177/0960327110364154] [PMID: 20197454]
[80]
Dey P, Chaudhuri TK. Pharmacological aspects of Nerium indicum Mill: A comprehensive review. Pharmacogn Rev 2014; 8(16): 156-62.
[http://dx.doi.org/10.4103/0973-7847.134250] [PMID: 25125887]
[81]
Hashem-Dabaghian F, Agah S, Taghavi-Shirazi M, Ghobadi A. Combination of Nigella sativa and honey in eradication of gastric Helicobacter pylori infection. Iran Red Crescent Med J 2016; 18(11): e23771-1.
[http://dx.doi.org/10.5812/ircmj.23771] [PMID: 28191328]
[82]
Khan SA, Khan AM, Karim S, Kamal MA, Damanhouri GA, Mirza Z. Panacea seed “Nigella”: A review focusing on regenerative effects for gastric ailments. Saudi J Biol Sci 2016; 23(4): 542-53.
[http://dx.doi.org/10.1016/j.sjbs.2014.10.001] [PMID: 27298589]
[83]
Dharmani P, Kuchibhotla VK, Maurya R, Srivastava S, Sharma S, Palit G. Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn. J Ethnopharmacol 2004; 93(2-3): 197-206.
[http://dx.doi.org/10.1016/j.jep.2004.02.029] [PMID: 15234753]
[84]
Trinovita E, Chany Saputri F, Mun’im A. Potential gastroprotective activity of rice bran (Oryza sativa L.) extracted by ionic liquid-microwave-assisted extraction against ethanol-induced acute gastric ulcers in rat model. Sci Pharm 2018; 86(3): 13.
[http://dx.doi.org/10.3390/scipharm86030035] [PMID: 30205486]
[85]
Jeong CS, Hyun JE, Kim YS, Lee E-S. Ginsenoside Rb1: The anti-ulcer constituent from the head of Panax ginseng. Arch Pharm Res 2003; 26(11): 906-11.
[http://dx.doi.org/10.1007/BF02980198] [PMID: 14661855]
[86]
Bi WP, Man HB, Man M-Q. Efficacy and safety of herbal medicines in treating gastric ulcer: A review. World J Gastroenterol 2014; 20(45): 17020-8.
[http://dx.doi.org/10.3748/wjg.v20.i45.17020] [PMID: 25493014]
[87]
Liu H, Lu X, Hu Y, Fan X. Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy. Pharmacol Res 2020; 161: 105263.
[http://dx.doi.org/10.1016/j.phrs.2020.105263] [PMID: 33127555]
[88]
Mostofa R, Ahmed S, Begum MM, et al. Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L. (Euphorbiaceae) leaves in experimental rats. BMC Complement Altern Med 2017; 17(1): 267.
[http://dx.doi.org/10.1186/s12906-017-1771-7] [PMID: 28511679]
[89]
Danladi S, Idris MA, Umar II. Review on pharmacological activities and phytochemical constituents of Phyllanthus niruri (Amarus). J Phytopharmacol 2018; 7(3): 341-8.
[http://dx.doi.org/10.31254/phyto.2018.7318]
[90]
Arawwawala LD, Arambewela LS, Ratnasooriya WD. Gastroprotective effect of Piper betle Linn. leaves grown in Sri Lanka. J Ayurveda Integr Med 2014; 5(1): 38-42.
[http://dx.doi.org/10.4103/0975-9476.128855] [PMID: 24812474]
[91]
Divyapraba M, Chitra P, Rameshwari KS. Anti-ulcer activity of Psidium guajava on pylorus ligation induced gastric ulcer in albino rats. Int J Pharm Sci Res 2021; 12(1): 443-9.
[92]
Ayres MC, Escorcio SP, da Costa DA, Chaves MH, Gerardo MVJ, Cavalheiro AJ. Chemical constituents from leaves of the Qualea grandiflora: Attribution of the NMR data of two diastereoisomeric acylated flavonoid glycosides. Quim Nova 2008; 31(6): 1481-4.
[http://dx.doi.org/10.1590/S0100-40422008000600038]
[93]
Hiruma-Lima CA, Santos LC, Kushima H, et al. Qualea grandiflora, a Brazilian “Cerrado” medicinal plant presents an important antiulcer activity. J Ethnopharmacol 2006; 104(1-2): 207-14.
[http://dx.doi.org/10.1016/j.jep.2005.09.002] [PMID: 16216456]
[94]
Ahmad H, Wadud A, Jahan N, Khazir M, Sofi G. Evaluation of Anti-ulcer activity of hydro alcoholic extract of Post Sumaq (Rhus coriaria Linn.) in ethanol induced gastric ulcer in experimental rats. Int Res J Med Sci 2013; 1(10): 7-12.
[95]
Sahoo SK, Sahoo HB, Priyadarshini D, Soundarya G, Kumar CK, Rani KU. Antiulcer activity of ethanolic extract of Salvadora indica (W.) leaves on albino rats. J Clin Diagn Res 2016; 10(9): 07-10.
[96]
Khatak M, Khatak S, Siddqui AA, Vasudeva N, Aggarwal A, Aggarwal P. Salvadora persica. Pharmacogn Rev 2010; 4(8): 209-14.
[http://dx.doi.org/10.4103/0973-7847.70920] [PMID: 22228963]
[97]
Naik HV, Chavan N, Himanshu A. Study of antiulcer activity of leaves of Sesbania grandiflora linn. (Fabaceae) study of antiulcer activity of leaves of Sesbania grandiflora linn. (Fabaceae). Res J Pharmacogn Phytochem 2012; 4(6): 322-5.
[98]
Hasan N, Osman H, Mohamad S, Chong WK, Awang K, Zahariluddin ASM. The chemical components of Sesbania grandiflora root and their antituberculosis activity. Pharmaceuticals (Basel) 2012; 5(8): 882-9.
[http://dx.doi.org/10.3390/ph5080882] [PMID: 24280680]
[99]
Muthu S, Anusuya N, Bhuvaneswari P. Antiulcerogenic effect of resin from Shorea robusta Gaertn. F. on experimentally induced ulcer models. Int J Pharm Pharm Sci 2012; 5: 269.
[100]
Jainu M, Devi CS. Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: Possible mechanism for the inhibition of acid formation. J Ethnopharmacol 2006; 104(1-2): 156-63.
[http://dx.doi.org/10.1016/j.jep.2005.08.064] [PMID: 16202548]
[101]
Taherpour A, Khodaei MM, Ameen BAH, et al. Chemical composition analysis of the essential oil of Solanumn nigrum L. by HS/SPME method and calculation of the biochemical coefficients of the components. Arab J Chem 2017; 10: 2372-5.
[http://dx.doi.org/10.1016/j.arabjc.2013.08.015]
[102]
Jain AS, Surana SJ, Naka K. Antiulcerogenic effects of Spathodea falcata against different experimental models. Asian J Pharm Clin Res 2009; 2(3): 54-9.
[103]
Kumar V, Van Staden J. A review of Swertia chirayita (Gentianaceae) as a traditional medicinal plant. Front Pharmacol 2016; 6: 308.
[http://dx.doi.org/10.3389/fphar.2015.00308] [PMID: 26793105]
[104]
Kalra P, Sharma S. Suman, Kumar S. Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models. J Pharm Bioallied Sci 2011; 3(2): 236-41.
[http://dx.doi.org/10.4103/0975-7406.80778] [PMID: 21687352]
[105]
Sharma P, Prakash T, Kotresha D, et al. Antiulcerogenic activity of Terminalia chebula fruit in experimentally induced ulcer in rats. Pharm Biol 2011; 49(3): 262-8.
[http://dx.doi.org/10.3109/13880209.2010.503709] [PMID: 21323478]
[106]
Chahal KK, Bhardwaj U, Kaushal S, Sandhu AK. Chemical composition and biological properties of Chrysopogon zizanioides (L.) Roberty syn. Vetiveria zizanioides (L.) Nash-A review. Indian J Nat Prod Resour 2015; 6: 251-60.
[107]
Nanjundaiah SM, Annaiah HNM, Dharmesh SM. Gastroprotective effect of ginger rhizome (Zingiber officinale) extract: Role of gallic acid and cinnamic acid in H(+), K(+)-ATPase/H. pylori inhibition and anti-oxidative mechanism. Evid Based Complement Alternat Med 2011; 2011: 249487.
[http://dx.doi.org/10.1093/ecam/nep060] [PMID: 19570992]
[108]
Vimala G, Gricilda Shoba F. A review on antiulcer activity of few Indian medicinal plants. Int J Microbiol 2014; 2014: 519590.
[http://dx.doi.org/10.1155/2014/519590]
[109]
Nariya MB, Shukla VJ, Ravishankar B, Jain SM. Comparison of gastroprotective effects of triphala formulations on stress-induced ulcer in rats. Indian J Pharm Sci 2011; 73(6): 682-7.
[http://dx.doi.org/10.4103/0250-474X.100252] [PMID: 23112406]
[110]
Hayat ZM. Chaudhry Alamgeer. Evaluation of a poly-herbal preparation for the treatment of peptic ulcer. Bangladesh J Pharmacol 2017; 12(2): 119-24.
[http://dx.doi.org/10.3329/bjp.v12i2.29980]
[111]
Uma S, Venugopalan R, Jayakumar VK, et al. Effect of a polyherbal liquid formulation on pylorus ligated gastric mucosal damage in albino Wistar rats 2011; 4(4): 1115-7.
[112]
Nair V, Arjuman A, Gopalakrishna HN, et al. Evaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats. Indian J Med Res 2010; 132: 218-23.
[PMID: 20716823]
[113]
Shirwaikar A, Ram HN, Mohapatra P. Antioxidant and antiulcer activity of aqueous extract of a polyherbal formulation. Indian J Exp Biol 2006; 44(6): 474-80.
[PMID: 16784118]
[114]
Bashir A, Hazarika I, Kp A, Ka S. Anti-ulcer activity of polyherbal formulation-RO12 on experimentally induced ulcer in rats. Int J Phytopharmacol 2014; 5(6): 406-10.
[115]
Iyswarya S, Visweswaran S, Banumathi V. Acute toxicity study and antiulcer activity of siddha polyherbal formulation narasinga rasayanam against aspirin plus pylorus ligation induced ulcer in rats. Int J Adv Res Biol Sci 2018; 5(2): 11-6.
[116]
Christian GJ, Mubarak H, Yamini K, et al. Anti-ulcer efficacy and safety of anda leghyam a polyherbal siddha formulation. Int J Pharm Sci Res 2014; 5(5): 1837-42.
[117]
Saikia T, Das B, Shil D. Formulation and evaluation of polyherbal anti ulcer tablets. EJBPS 2018; 5(7): 307-13.
[118]
Sumalatha G, Jayapal Reddy G. Design, development and evaluation of polyherbal floating formulations for gastric ulcer. Int J Pharm Biol Sci 2016; 6(1): 254-61.
[119]
Hafeel MH, Mobeen A, Rizwana AA, Yasir M. Therapeutic evaluation of Unani formulation in peptic ulcer single blind, before and after comparison clinical trial. Int J Curr Adv Res 2020; 9(8): 23019-27.
[120]
Om I, Ao A. Anti-peptic ulcer potential of a polyherbal mixture in indomethacin-induced rat model. J Complement Med Alt Healthcare 2018; 5(4): 1-5.
[http://dx.doi.org/10.19080/JCMAH.2018.06.555670]
[121]
Alam S, Mohiuddin M, Swamy KL, Baig A, Reddy MV. Evaluation of antiulcer and antioxidant activity of polyherbal formulation in Wistar rats. Int J Pharm Phytopharmacol Res 2013; 2(6): 400-6.
[122]
Shanthi A, Radha R, Jaysree N. Antiulcer activity of newly formulated herbal capsule. Asian J Pharm Clin Res 2011; 4(3): 8689.
[123]
Devaraj VC, Krishna BG. Antiulcer activity of a Polyherbal Formulation (PHF) from Indian medicinal plants. Chin J Nat Med 2013; 11(2): 145-8.
[http://dx.doi.org/10.1016/S1875-5364(13)60041-2] [PMID: 23787181]
[124]
Kumari N, Mangali SB, Sree D. Evaluation of antiulcer potential of polyherbal preparation against experimentally induced ulcers in rats. IJPPR 2016; 8(12): 2007-10.
[125]
Satyanarayanaa T, Dwarakanadha RP, Swarnalathaa D, et al. Evaluation of anti ulcer activity by poly herbal formulation on indomethacin induced gastric ulcers. Int J Chem Sci 2010; 8(3): 1537-44.
[126]
Jain P, Satapathy T, Pandey RK. Acaricidal activity and clinical safety of arecoline hydrobromide on calves infested with cattle tick Rhipicephalus microplus (Acari: Ixodidae). Vet Parasitol 2021; 298(May): 109490.
[http://dx.doi.org/10.1016/j.vetpar.2021.109490] [PMID: 34271319]
[127]
Jain P, Satapathy T, Pandey RK. First report on efficacy of Citrus limetta seed oil in controlling cattle tick Rhipicephalus microplus in red Sahiwal calves. Vet Parasitol 2021; 296: 109508.
[http://dx.doi.org/10.1016/j.vetpar.2021.109508] [PMID: 34218174]
[128]
Jain P, Satapathy T, Kumar R. Acaricidal activity and biochemical analysis of Citrus limetta seed oil for controlling ixodid tick Rhipicephalus microplus infesting cattle. Syst Appl Acarol 2021; 26(7): 1350-60.
[http://dx.doi.org/10.11158/saa.26.7.13]
[129]
Jain P, Satapathy T, Pandey RK. Rhipicephalus microplus (acari: Ixodidae): Clinical safety and potential control by topical application of cottonseed oil (Gossypium sp.) on cattle. Exp Parasitol 2020; 219: 108017.
[http://dx.doi.org/10.1016/j.exppara.2020.108017] [PMID: 33039477]
[130]
Jain P, Satapathy T, Pandey RK. Rhipicephalus microplus: A parasite threatening cattle health and consequences of herbal acaricides for upliftment of livelihood of cattle rearing communities in Chhattisgarh. Biocatal Agric Biotechnol 2020; 26: 101611.
[http://dx.doi.org/10.1016/j.bcab.2020.101611]
[131]
Jain P, Satapathy T, Pandey RK. Efficacy of arecoline hydrobromide against cattle tick Rhipicephalus (Boophilus) microplus. Int J Acarol 2020; 46(4): 268-75.
[http://dx.doi.org/10.1080/01647954.2020.1765018]
[132]
Jain P, Satapathy T, Pandey RK. First report on ticks (Acari: Ixodidae) controlling activity of cottonseed oil (Gossypium sp.). Int J Acarol 2020; 46(4): 263-7.
[http://dx.doi.org/10.1080/01647954.2020.1767203]
[133]
Jain P, Satapathy T, Pandey RK. A mini review of methods to control ticks population infesting cattle in Chhattisgarh with special emphasis on herbal acaricides. IJNPR 2020; 11(12): 217-23.
[134]
Jain A, Jain P, Parihar DK. Comparative study of in-vitro antidiabetic and antibacterial activity of non-conventional curcuma species. JBAPN 2019; 9(6): 457-64.
[http://dx.doi.org/10.1080/22311866.2019.1710253]
[135]
Jain A, Parihar DK. Antibacterial, biofilm dispersal and antibiofilm potential of alkaloids and flavonoids of Curcuma. Biocatal Agric Biotechnol 2018; 16: 677-82.
[http://dx.doi.org/10.1016/j.bcab.2018.09.023]
[136]
Jain A, Parihar DK. Molecular marker based genetic diversity study of wild, cultivated and endangered species of Curcuma from Chhattisgarh region for in situ conservation. Biocatal Agric Biotechnol 2019; 18: 101033.
[http://dx.doi.org/10.1016/j.bcab.2019.101033]
[137]
Rao SP, Jain P, Rathore P, Singh VK. Larvicidal and knockdown activity of citrus Limetta risso oil against dengue virus vector. Indian J Nat Prod Resour 2016; 7(3): 256-60.
[138]
Rao SP, Amrit I, Jain P, Singh V. Antiulcer activity of agnimukha churna. Int J Ayurveda Pharma Res 2014; 2(2): 40-6.
[139]
Kumar V, Rathore K, Jain P, Ahmed Z. Biological activity of Bauhinia racemose against diabetes and interlinked disorders like obesity and hyperlipidemia. Clinical Phytoscience 2017; 3: 7.
[http://dx.doi.org/10.1186/s40816-017-0044-9]
[140]
Kumar V, Jain P, Rathore K, Ahmed Z. Biological evaluation of Pupalia lappacea for antidiabetic, antiadipogenic, and hypolipidemic activity both in vitro and in vivo. Scientifica (Cairo) 2016; 2016: 1062430.
[http://dx.doi.org/10.1155/2016/1062430] [PMID: 26942038]
[141]
Rathore K, Singh V, Jain P, Rao SP, Ahmed Z, Thakur VS. In-vitro and in-vivo antiadipogenic, antidiabetic and hypolipidemic activity of Diospyros melanoxylon (Roxb.). J Ethnopharmacol 2014; 155: 1171-6.
[http://dx.doi.org/10.1016/j.jep.2014.06.050] [PMID: 25010927]
[142]
Singh P, Jain P, Pandey R, Shukla SS. Phytotherapeutic review on diabetes Spatula DD 2016; 6(2): 1.
[143]
Sharwan G, Jain P, Pandey R, Shukla SS. Toxicity and safety profiles of methanolic extract of Pistacia integerrima J. L. Stewart ex Brandis (PI) for wistar rats. J Pharmacopuncture 2016; 19(3): 253-8.
[http://dx.doi.org/10.3831/KPI.2016.19.027] [PMID: 27695635]
[144]
Jain P, Pandey R, Shukla SS. Reproductive and developmental toxicity study of talisadya churna: An ancient polyherbal formulation. IAJPR 2016; 6(5): 5641-53.
[145]
Jain P, Pandey R, Shukla SS. Acute and subacute toxicity studies of polyherbal formulation talisadya churna in experimental animal model. MJPMS 2015; 1(1): 7-10.
[146]
Sharwan G, Jain P, Pandey R, Shukla SS. Toxicity profile of traditional herbal medicine. J Ayu Herb Med 2015; 1(3): 81-90.
[147]
Jain P, Rao SP, Singh V, Pandey R, Shukla SS. Acute and sub-acute toxicity studies of an ancient ayurvedic formulation: Agnimukha churna. Columbia J Pharm Sci 2014; 1: 18-22.

Rights & Permissions Print Cite
Article Metrics
15
1
© 2024 Bentham Science Publishers | Privacy Policy