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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

中枢神经系统炎症：了解阿尔茨海默病发病机制的各个方面

卷 19, 期 1, 2022

发表于: 11 February, 2022

页: [16 - 31] 页: 16

弟呕挨: 10.2174/1567205018666211202143935

open access plus

摘要

阿尔茨海默病是一种进行性和致命的神经退行性疾病，也是全球痴呆症最常见的原因之一。目前，早期诊断和监测这种疾病的敏感性和特异性不足的方法促使人们寻找新的工具。大量文献资料表明，阿尔茨海默病 (AD) 的发病机制不仅限于神经元区室，还涉及多种免疫机制。神经炎症已被认为是 AD 病理学中一个非常重要的过程。根据疾病的阶段，它似乎在认知障碍的发展中发挥多效性作用，包括神经保护和神经退行性。越来越多的证据表明，炎症蛋白可以被认为是疾病进展的生物标志物。因此，本综述总结了一些炎症分子的作用及其在检测和监测痴呆严重程度方面的潜在用途。本文还对导致痴呆症发展的新机制提供了有价值的见解，这可能有助于发现可能的抗炎治疗。

关键词: 神经炎症、阿尔茨海默病、痴呆症、生物标志物、神经变性、趋化因子、白细胞介素

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