Abstract
Hydrogen sulfide (H2S) is regarded as one of the air pollutants with a rotten egg smell. However, it is recently discovered that endogenous H2S has important physiological and pathological functions. Cystathionine- β synthase (CBS) and cystathionine- γ lyase (CSE) play key roles in the synthesis of H2S, and CSE is also a major H2S-formation enzyme in the cardiovascular system. Vascular inflammation is one of the most important pathological processes in a variety of vascular diseases. The present review aimed at exploring the role of hydrogen sulfide and its signaling in vascular inflammation during vascular diseases including atherosclerosis, systemic hypertension, pulmonary hypertension (PAH), and vascular balloon injury.
Keywords: Atherosclerosis, balloon injury, hydrogen sulfide, hypertension, inflammation, NF-κB pathway, pulmonary hypertension.
Graphical Abstract
Current Signal Transduction Therapy
Title:Hydrogen Sulfide Regulates Vascular Inflammation and its Related Signaling Pathways
Volume: 9 Issue: 2
Author(s): Shasha Feng, Junbao Du, Selena Y. Chen, Wen Yu, Chaoshu Tang and Hongfang Jin
Affiliation:
Keywords: Atherosclerosis, balloon injury, hydrogen sulfide, hypertension, inflammation, NF-κB pathway, pulmonary hypertension.
Abstract: Hydrogen sulfide (H2S) is regarded as one of the air pollutants with a rotten egg smell. However, it is recently discovered that endogenous H2S has important physiological and pathological functions. Cystathionine- β synthase (CBS) and cystathionine- γ lyase (CSE) play key roles in the synthesis of H2S, and CSE is also a major H2S-formation enzyme in the cardiovascular system. Vascular inflammation is one of the most important pathological processes in a variety of vascular diseases. The present review aimed at exploring the role of hydrogen sulfide and its signaling in vascular inflammation during vascular diseases including atherosclerosis, systemic hypertension, pulmonary hypertension (PAH), and vascular balloon injury.
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Cite this article as:
Feng Shasha, Du Junbao, Chen Y. Selena, Yu Wen, Tang Chaoshu and Jin Hongfang, Hydrogen Sulfide Regulates Vascular Inflammation and its Related Signaling Pathways, Current Signal Transduction Therapy 2014; 9 (2) . https://dx.doi.org/10.2174/1574362409666141201204902
DOI https://dx.doi.org/10.2174/1574362409666141201204902 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
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