Abstract
Hydrogen sulfide (H2S) is a well-known toxic gas with the smell of rotten eggs. Recent studies have shown that H2S is generated in vivo in human and animal organisms and that it participates in many pathophysiological processes. H2S is produced endogenously in mammalian tissues from L-cysteine metabolism mainly by 3 enzymes: cystathionine β-synthetase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptosulfurtransferase (MST). H2S may not only function as a neuromodulator in the central nervous system but it also relaxes gastrointestinal smooth muscles. More importantly, present evidence shows that H2S exerts regulatory effects on the pathogenesis of various cardiovascular diseases such as hypertension, pulmonary hypertension, shock and myocardial injury. The genomic basis of cystathioninuria in humans is 2 nonsense and 2 sense mutations in CSE. This review reveals that H2S is a new endogenous gaseous transmitter in the cardiovascular system.
Keywords: cysteine aminotransferase, CBS knock-out mice, 3-mercaptopyruvate, neuromodulator, Myocardial damage, hypertension
Current Vascular Pharmacology
Title: Hydrogen Sulfide as a New Endogenous Gaseous Transmitter in the Cardiovascular System
Volume: 4 Issue: 1
Author(s): Chaoshu Tang, Xiaohui Li and Junbao Du
Affiliation:
Keywords: cysteine aminotransferase, CBS knock-out mice, 3-mercaptopyruvate, neuromodulator, Myocardial damage, hypertension
Abstract: Hydrogen sulfide (H2S) is a well-known toxic gas with the smell of rotten eggs. Recent studies have shown that H2S is generated in vivo in human and animal organisms and that it participates in many pathophysiological processes. H2S is produced endogenously in mammalian tissues from L-cysteine metabolism mainly by 3 enzymes: cystathionine β-synthetase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptosulfurtransferase (MST). H2S may not only function as a neuromodulator in the central nervous system but it also relaxes gastrointestinal smooth muscles. More importantly, present evidence shows that H2S exerts regulatory effects on the pathogenesis of various cardiovascular diseases such as hypertension, pulmonary hypertension, shock and myocardial injury. The genomic basis of cystathioninuria in humans is 2 nonsense and 2 sense mutations in CSE. This review reveals that H2S is a new endogenous gaseous transmitter in the cardiovascular system.
Export Options
About this article
Cite this article as:
Tang Chaoshu, Li Xiaohui and Du Junbao, Hydrogen Sulfide as a New Endogenous Gaseous Transmitter in the Cardiovascular System, Current Vascular Pharmacology 2006; 4 (1) . https://dx.doi.org/10.2174/157016106775203144
DOI https://dx.doi.org/10.2174/157016106775203144 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Antioxidant Status and Energy State of Erythrocytes in Alzheimer Dementia: Probing for Markers
CNS & Neurological Disorders - Drug Targets Role of Angiotensin-1-Receptor Blockers In Cardiorenal Disease
Current Drug Therapy Preparation of 1,4-dihydropyridine Derivatives Using Perchloric Acid Adsorbed on Magnetic Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Coated with Silica
Current Nanoscience Nitric Oxide and Arginine Dysregulation: A Novel Pathway to Pulmonary Hypertension in Hemolytic Disorders
Current Molecular Medicine Air Pollution Exposure and Blood Pressure: An Updated Review of the Literature
Current Pharmaceutical Design Pathogenetic Pathways of Cardiorenal Syndrome and their Possible Therapeutic Implications
Current Pharmaceutical Design A<sub>3</sub> Adenosine Receptor: A Plausible Therapeutic Target for Cardio-Protection in Diabetes
Recent Patents on Cardiovascular Drug Discovery Current Management of Peripheral Vascular Disease: Where is the Evidence?
Cardiovascular & Hematological Agents in Medicinal Chemistry Mechanism of Organophosphates (Nerve Gases and Pesticides) and Antidotes: Electron Transfer and Oxidative Stress
Current Medicinal Chemistry Effect of Antihypertensive Drugs on Cognition and Behavioral Symptoms of Patients with Alzheimer’s Disease: A Meta-analysis
Current Pharmaceutical Biotechnology The Neuropharmacology of (-)-Stepholidine and its Potential Applications
Current Neuropharmacology siRNA Silencing of Gene Expression in Trabecular Meshwork: RhoA siRNA Reduces IOP in Mice
Current Molecular Medicine The Role of Systemic Treatment and Radiotherapy in Malignant Mesothelioma
Current Respiratory Medicine Reviews Significance of High Levels of Endogenous Melatonin in Mammalian Cerebrospinal Fluid and in the Central Nervous System
Current Neuropharmacology Pulse Wave Velocity Assessment for Cardiovascular Risk Prognostication in ESKD: Weighting Recent Evidence
Current Vascular Pharmacology Mechanisms Explaining the Influence of Subclinical Hypothyroidism on the Onset and Progression of Chronic Heart Failure
Endocrine, Metabolic & Immune Disorders - Drug Targets Dermatological, Cardiovascular and Neurological Morphohistopathological Effects of Fluoropyrimidine-based Chemotherapy in Humans
Clinical Cancer Drugs Preface [Hot Topic: Antihypertensive Drugs (Executive Editor : Gregory Y.H. Lip)].
Current Pharmaceutical Design Patent Selections
Recent Patents on Cardiovascular Drug Discovery Editorial: Cocaine and Cerebral Small Vessel: Is it a Negative Factor for Intravenous Thrombolysis?
Current Vascular Pharmacology