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Review Article

点击树突状分子药物传递系统合成中的反应

卷 29, 期 19, 2022

发表于: 14 January, 2022

页: [3445 - 3470] 页: 26

弟呕挨: 10.2174/0929867328666211027124724

价格: $65

摘要

药物传递系统是为药物的靶向传递和控制释放而设计的。在作为药物传递系统的材料中，树状大分子因其特性和结构特性而受到越来越多的关注。树突状分子-纳米载体制剂的使用提高了安全性和生物利用度，增加了在水中的溶解度，提高了稳定性和药代动力学特性，并使目标药物能够有效地递送到特定的部位。然而，通过聚合或发散的方法合成树突状结构存在缺陷和局限性，破坏了与设计和施工相关的方面，从而减缓了从学术界向工业界的转移。从这个意义上说，点击化学的实现在过去几年中受到越来越多的关注，因为它提供了新的获得高产量和高单分散性的有效方法。本文综述了2015年至2021年初使用点击反应构建树突状分子药物传递系统的最新策略。本文综述的树突状结构是基于β-环糊精（β-CD）、聚（酰胺胺）(PAMAM)、树突状聚（赖氨酸）(PLLD)、二甲基丙酸（双MPA）、磷酰胺(PAD)和聚（丙炔醇-4-巯基丁基(PPMA)。

关键词: 树状大分子，点击化学，药物传递系统，生物材料，纳米载体，合成。

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