Generic placeholder image

Current Vascular Pharmacology

Editor-in-Chief

ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Using Extracellular Matrix-Derived Peptides to Alter the Microenvironment for Myocardial Repair

Author(s): Shirley S. Mihardja and Randall J. Lee

Volume 10, Issue 3, 2012

Page: [342 - 346] Pages: 5

DOI: 10.2174/157016112799959341

Price: $65

Abstract

Myocardial repair remains a major challenge for both cellular and tissue engineering approaches. Several studies have been conducted looking at utilizing extracellular matrix-based therapies to promote repair after a myocardial infarction. In this review, strategies for treating myocardial infarctions using extracellular matrix-derived peptides are discussed. Using an ischemia/reperfusion myocardial infarction rodent model, we showed that extracellular-matrix-derived peptides were able to induce angiogenesis and alter the negative remodeling seen after a myocardial infarction. This therapy opens up a potentially new non-invasive strategy for repairing damaged cardiac tissue.

Keywords: Extracellular matrix, myocardial infarction, tissue engineering, cardiac repair, angiogenesis


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy