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Review Article

乙型肝炎病毒突变与肝病和肝细胞癌风险之间的关联

卷 22, 期 6, 2022

发表于: 16 August, 2021

页: [514 - 523] 页: 10

弟呕挨: 10.2174/1566524021666210816094412

价格: $65

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摘要

乙型肝炎病毒 [HBV] 是描述最好的肝炎病毒，分布在世界各地，可能导致慢性和急性肝病、肝硬化和肝细胞癌。尽管针对 HBV 的治疗取得了进展，但 HBV 复制和宿主免疫压力所需的易出错逆转录酶导致基因型、亚基因型和突变病毒的不断进化和出现；因此，HBV 仍将是全球主要的医疗保健问题。这篇综述文章主要关注与隐匿性 HBV 感染、免疫逃逸、疫苗失败以及最终导致肝硬化和 HCC 相关的 HBV 突变。目前的研究表明preS/S区突变与疫苗失败、免疫逃逸、隐匿性HBV感染和HCC的发生有关。而 P 区突变可能导致对 NA 抗病毒药物的耐药性。 PreC/C 区突变与 HBeAg 阴性、免疫逃逸和持续性肝炎有关。此外，X 区突变在 HCC 发展中起重要作用。

关键词: 乙型肝炎病毒、突变、肝细胞癌、肝硬化、HbsAg、HbcAg、HbeAg。

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