Synthesis, DNA Binding, Docking and Photoclevage Studies of Novel Benzo[b][1,8]naphthyridines

Title: Synthesis, DNA Binding, Docking and Photoclevage Studies of Novel Benzo[b][1,8]naphthyridines

Volume: 5 Issue: 5

Author(s): T.R. Ravikumar Naik, H.S. Bhojya Naik, H.R. Prakash Naik, P. J. Bindu, B. G. Harish and V. Krishna

Affiliation:

Keywords: Synthesis, DNA minor groove, Photoclevage, Docking studies, Benzo[b][1,8]naphthyridines

Abstract: The synthesis and docking studies of novel benzo[b][1,8]naphthyridines are described. The docking studies show that the derivatives prefer to bind the AT-rich region of double stranded DNA (ds-DNA). The maximum binding energy -7.16 (kcal/mol) was observed for benzo[b][1,8]naphthyridine-5-thiol 5a and it is a better candidate as an enantioselective binder to ds-DNA than the other derivatives of benzo[b][1,8]naphthyridines. When photoirradiated at 365 nm, benzo[1,8]-naphthyridines have been found to promote the photocleavage of plasmid pUC19 DNA.

Cite this article as:

Naik Ravikumar T.R., Naik Bhojya H.S., Naik Prakash H.R., Bindu J. P., Harish G. B. and Krishna V., Synthesis, DNA Binding, Docking and Photoclevage Studies of Novel Benzo[b][1,8]naphthyridines, Medicinal Chemistry 2009; 5 (5) . https://dx.doi.org/10.2174/157340609789117804