Antibacterial Activity of Lipophilic Fluoroquinolone Derivatives

Title: Antibacterial Activity of Lipophilic Fluoroquinolone Derivatives

Volume: 5 Issue: 5

Author(s): Camila G. de Almeida, Claudio G. Diniz, Vania L. Silva, Mauricio F. Saraiva, Mireille Le Hyaric and Mauro V. de Almeida

Affiliation:

Keywords: Fluoroquinolones, lipophilicity, antibacterial activity, gatifloxacin, moxifloxacin, diamines, alkyl chains

Abstract: We report in this work the antibacterial evaluation of 12 lipophilic fluoroquinolone derivatives containing diaminoalkyl side chains at C-7 position. The compounds were investigated against 15 bacterial strains including Gramnegative and Gram-positive species of clinical and microbiological importance. Three compounds (5, 10 and 11) were as active as or more efficient than gatifloxacin against Gram-positive bacteria M. lentus. When compared with gatifloxacin compound 10 was 16 times more active. Two compounds (11 and 12) were twice more active than the reference compound against S. aureus.

Cite this article as:

de Almeida G. Camila, Diniz G. Claudio, Silva L. Vania, Saraiva F. Mauricio, Le Hyaric Mireille and de Almeida V. Mauro, Antibacterial Activity of Lipophilic Fluoroquinolone Derivatives, Medicinal Chemistry 2009; 5 (5) . https://dx.doi.org/10.2174/157340609789117859