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Current Drug Delivery

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ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

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Research Article

Eggshell Membrane Based Turmeric Extract Loaded Orally Disintegrating Films

Author(s): Merve Deniz Köse, Nazlı Ungun and Oguz Bayraktar*

Volume 19, Issue 5, 2022

Published on: 10 January, 2022

Page: [547 - 559] Pages: 13

DOI: 10.2174/1567201818666210708123449

Price: $65

Abstract

Background: The increasing interest in using natural bioactive compounds as new drug candidates due to their low solubility led to designing and developing novel drug delivery systems. Out of those, orally disintegrating films (ODFs) are a very eminent drug delivery system among pediatrics and geriatrics.

Objective: In our study, the solvent casting method was used to prepare eggshell membrane-based and turmeric extract loaded orally disintegrating films.

Methods: Characterization of the prepared films was done with FTIR, AFM, and SEM analysis. The release profile of the turmeric extract was determined and fitted to the mathematical models.

Results: AFM results showed that the best interaction between components was achieved in Film 2. The highest cumulative release percentage was obtained for the film with 7.5% (w/w) turmeric extract (Film-2) as 41.98%, based on the HPLC measurements. The Higuchi model was the best-- fitted model for Film 2.

Conclusion: In this study, SEP and CMCH were used for the first time as biopolymers to prepare the orally disintegrating film. Turmeric extract was successfully integrated into films prepared from SEP and CMCH.

Keywords: Orally disintegrating films, eggshell membrane, turmeric extract, curcuminoids, biopolymers, plant-based bioactive compounds.

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[1]
Bala, R.; Pawar, P.; Khanna, S.; Arora, S. Orally dissolving strips: A new approach to oral drug delivery system. Int. J. Pharm. Investig., 2013, 3(2), 67-76.
[http://dx.doi.org/10.4103/2230-973X.114897] [PMID: 24015378]
[2]
Borges, A. F.; Silva, C.; Coelho, J. F. J.; Simões, S. Oral films: Current status and future perspectives: I-galenical development and quality attributes. J. Cont. Rel., 2015, 1-19.
[3]
Joshua, J.M.; Hari, R.; Jyothish, F.K.; Surendran, S.A. Fast dissolving oral thin films: An effective dosage form for quick releases. Int. J. Pharm. Sci. Rev. Res., 2016, 38(1), 282-289.
[4]
Yasir, M.; Nagar, P.; Chauhan, I. Drug Invention Today Insights into Polymers: Film Formers in Mouth Dissolving Films. Drug Invent. Today, 2011, 3(12), 280-289.
[5]
Thakur, N.; Bansal, M.; Sharma, N.; Yadav, G.; Khare, P. Overview, a novel approach of fast dissolving films and their patients. Adv. Biol. Res. (Faisalabad), 2013, 7(2), 50-58.
[6]
Hanif, M.; Zaman, M.; Chaurasiya, V. Polymers used in buccal film: A review. Des. Monomers Polym., 2014, 18(2), 105-111.
[http://dx.doi.org/10.1080/15685551.2014.971389]
[7]
Mourya, V.K.; Inamdar, N.N.; Tiwari, A. Carboxymethyl chitosan and its applications. Adv. Mater. Lett., 2010, 1(1), 11-33.
[http://dx.doi.org/10.5185/amlett.2010.3108]
[8]
Yi, F.; Lu, J.W.; Guo, Z.X.; Yu, J. Mechanical properties and biocompatibility of soluble eggshell membrane protein/poly(vinyl alcohol) blend films. J. Biomater. Sci. Polym. Ed., 2006, 17(9), 1015-1024.
[http://dx.doi.org/10.1163/156856206778365997] [PMID: 17094639]
[9]
Sah, M.K.; Rath, S.N. Soluble eggshell membrane: A natural protein to improve the properties of biomaterials used for tissue engineering applications. Mater. Sci. Eng. C, 2016, 67, 807-821.
[http://dx.doi.org/10.1016/j.msec.2016.05.005] [PMID: 27287179]
[10]
Araújo, C.C.; Leon, L.L. Biological activities of Curcuma longa L. Mem. Inst. Oswaldo Cruz, 2001, 96(5), 723-728.
[http://dx.doi.org/10.1590/S0074-02762001000500026] [PMID: 11500779]
[11]
Mazzarino, L.; Borsali, R.; Lemos-Senna, E. Mucoadhesive films containing chitosan-coated nanoparticles: A new strategy for buccal curcumin release. J. Pharm. Sci., 2014, 103(11), 3764-3771.
[http://dx.doi.org/10.1002/jps.24142] [PMID: 25187001]
[12]
Han, J.; Chang, Y.; Britten, M.; St-Gelais, D.; Champagne, C.P.; Fustier, P.; Lacroix, M. Interactions of phenolic compounds with milk proteins. Eur. Food Res. Technol., 2019, 245(9), 1881-1888.
[http://dx.doi.org/10.1007/s00217-019-03293-1]
[13]
Yi, F.; Yu, J.; Guo, Z.X.; Zhang, L.X.; Li, Q. Natural bioactive material: A preparation of soluble eggshell membrane protein. Macromol. Biosci., 2003, 3(5), 234-237.
[http://dx.doi.org/10.1002/mabi.200390030]
[14]
Jangle, R.D.; Thorat, B.N. Reversed-phase high-performance liquid chromatography method for analysis of curcuminoids and curcuminoid-loaded liposome formulation. Indian J. Pharm. Sci., 2013, 75(1), 60-66.
[http://dx.doi.org/10.4103/0250-474X.113555] [PMID: 23901162]
[15]
Fonseca-Santos, B.; Gremião, M.P.D.; Chorilli, M. A simple reversed-phase high-performance liquid chromatography (hplc) method for determination of in situ gelling curcumin-loaded liquid crystals in vitro performance tests. Arab. J. Chem., 2017, 10(7), 1029-1037.
[http://dx.doi.org/10.1016/j.arabjc.2016.01.014]
[16]
Athira, G.K.; Jyothi, A.N. Preparation and characterization of curcumin loaded cassava starch nanoparticles with improved cellular absorption. Int. J. Pharm. Pharm. Sci., 2014, 6(10), 171-176.
[17]
Siahaan, P.; Mentari, N.C.; Wiedyanto, U.O.; Hudiyanti, D.; Hildayani, S.Z.; Laksitorini, M.D. The optimum conditions of carboxymethyl chitosan synthesis on drug delivery application and its release of kinetics study. Indones. J. Chem., 2017, 17(2), 291-300.
[http://dx.doi.org/10.22146/ijc.24252]
[18]
Jabbari, M.; Razmi, H. New solid phase microextraction fiber based on an eggshell membrane coating for determination of polycyclic aromatic hydrocarbons. RSC Advances, 2016, 6(89), 86477-86484.
[http://dx.doi.org/10.1039/C6RA10815F]
[19]
Chen, F.P.; Li, B.S.; Tang, C.H. Nanocomplexation between curcumin and soy protein isolate: influence on curcumin stability/bioaccessibility and in vitro protein digestibility. J. Agric. Food Chem., 2015, 63(13), 3559-3569.
[http://dx.doi.org/10.1021/acs.jafc.5b00448] [PMID: 25779681]
[20]
Kannamangalam Vijayan, U.; Shah, N.N.; Muley, A.B.; Singhal, R.S. Complexation of curcumin using proteins to enhance aqueous solubility and bioaccessibility: pea protein vis-à-vis whey protein. J. Food Eng., 2021, 292, 110258.
[http://dx.doi.org/10.1016/j.jfoodeng.2020.110258]
[21]
Tapal, A.; Tiku, P.K. Complexation of curcumin with soy protein isolate and its implications on solubility and stability of curcumin. Food Chem., 2012, 130(4), 960-965.
[http://dx.doi.org/10.1016/j.foodchem.2011.08.025]
[22]
Han, U.; Seo, Y.; Hong, J. Effect of pH on the structure and drug release profiles of layer-by-layer assembled films containing polyelectrolyte, micelles, and graphene oxide. Sci. Rep., 2016, 6(1), 24158.
[http://dx.doi.org/10.1038/srep24158] [PMID: 27052827]
[23]
Labuckas, D.O.; Maestri, D.M.; Perelló, M.; Martínez, M.L.; Lamarque, A.L. Phenolics from walnut (Juglans Regia L.) kernels: Antioxidant activity and interactions with proteins. Food Chem., 2008, 107(2), 607-612.
[http://dx.doi.org/10.1016/j.foodchem.2007.08.051] [PMID: 26059139]
[24]
Ozdal, T.; Capanoglu, E.; Altay, F. A review on protein-phenolic interactions and associated changes. Food Res. Int., 2013, 51(2), 954-970.
[http://dx.doi.org/10.1016/j.foodres.2013.02.009]
[25]
Ali, H.; Alli, I.; Ismail, A.; Kermasha, S. Protein-phenolic interactions in food. Eurasian J. Anal. Chem., 2012, 7(3), 123-133.
[26]
Bajpai, S.K.; Chand, N.; Ahuja, S. Investigation of curcumin release from chitosan/cellulose micro crystals (CMC) antimicrobial films. Int. J. Biol. Macromol., 2015, 79, 440-448.
[http://dx.doi.org/10.1016/j.ijbiomac.2015.05.012] [PMID: 26003303]
[27]
Irfan, M.; Rabel, S.; Bukhtar, Q.; Qadir, M.I.; Jabeen, F.; Khan, A. Orally disintegrating films: A modern expansion in drug delivery system. Saudi Pharm. J., 2016, 24(5), 537-546.
[http://dx.doi.org/10.1016/j.jsps.2015.02.024] [PMID: 27752225]
[28]
Aniesrani Delfiya, D.; Thangavel, K. In vitro release kinetics of spray dried curcumin-loaded egg albumin microparticles. Int. J. Herb. Med., 2017, 5(3), 45-48.

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