Recent Advances in the Local Drug Delivery Systems for Improvement of
Anticancer Therapy

Davinder       Singh; Prabhjot       Kaur; Shivani       Attri; Sharabjit       Singh; Palvi       Sharma; Pallavi       Mohana; Kirandeep       Kaur; Harneetpal       Kaur; Gurdeep       Singh; Farhana       Rashid; Dilpreet       Singh; Avinash       Kumar; Ankita       Rajput; Neena       Bedi; Balbir       Singh; Harpal    Singh    Buttar; Saroj       Arora
doi:10.2174/1567201818666211214112710
Abstract

The conventional anticancer chemotherapies not only cause serious toxic effects but also produce resistance in tumor cells exposed to long-term therapy. Usually, the selective killing of metastasized cancer cells requires long-term therapy with higher drug doses because the cancer cells develop resistance due to the induction of poly-glycoproteins (P-gps) that act as a transmembrane efflux pump to transport drugs out of the cells. During the last few decades, scientists have been exploring new anticancer drug delivery systems such as microencapsulation, hydrogels, and nanotubes to improve bioavailability, reduce drug-dose requirement, decrease multiple drug resistance, and save normal cells as non-specific targets. Hopefully, the development of novel drug delivery vehicles (nanotubes, liposomes, supramolecules, hydrogels, and micelles) will assist in delivering drug molecules at the specific target site and reduce undesirable side effects of anticancer therapies in humans. Nanoparticles and lipid formulations are also designed to deliver a small drug payload at the desired tumor cell sites for their anticancer actions. This review will focus on the recent advances in drug delivery systems and their application in treating different cancer types in humans.
Keywords: Nanotubes, liposomes, supramolecules, hydrogels, micelles, anticancer agents.
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DOI https://dx.doi.org/10.2174/1567201818666211214112710	Print ISSN 1567-2018
Publisher Name Bentham Science Publisher	Online ISSN 1875-5704
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