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Anti-Cancer Agents in Medicinal Chemistry

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ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

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Review Article

lncRNAs as Hallmarks for Individualized Treatment of Gastric Cancer

Author(s): Jing Wu, Shan Xu, Wei Li, Yuru Lu, Yu Zhou, Ming Xie, Yichen Luo, Yijing Cao , Yan He, Tiebing Zeng* and Hui Ling*

Volume 22, Issue 8, 2022

Published on: 06 July, 2021

Page: [1440 - 1457] Pages: 18

DOI: 10.2174/1871520621666210706113102

Price: $65

Abstract

Gastric cancer is a global cancer with a high mortality rate. A growing number of studies have found the abnormal expression of lncRNA (long noncoding RNA) in many tumors, which plays a role in promoting or inhibiting cancer. Similarly, lncRNA abnormal expression plays an essential biological function in gastric cancer. This article focuses on lncRNA involvement in the development of gastric cancer in terms of cell cycle disorder, apoptosis inhibition, metabolic remodeling, promotion of tumor inflammation, immune escape, induction of angiogenesis, and Epithelial Mesenchymal Transition (EMT). The involvement of lncRNA in the development of gastric cancer is related to drug resistance, such as cisplatin and multi-drug resistance. It can also be used as a potential marker for the diagnosis and prognosis of gastric cancer and a target for the treatment. With an in-depth understanding of the mechanism of lncRNA in gastric cancer, new ideas for personalized treatment of gastric cancer are expected.

Keywords: Gastric cancer, lncRNAs, hallmarks, drug resistance, target, EMT.

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