Abstract
Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time. The current review considers lipid metabolism and inflammation as well as nutritional and pharmacological agents affecting atherosclerosis, using the apo E knock out mouse model.
Keywords: Apolipoprotein E, knock out, atherosclerosis
Current Pharmaceutical Design
Title: Apolipoprotein E Knockout Models
Volume: 14 Issue: 4
Author(s): Genovefa Kolovou, Katherine Anagnostopoulou, Dimitri P. Mikhailidis and Dennis V. Cokkinos
Affiliation:
Keywords: Apolipoprotein E, knock out, atherosclerosis
Abstract: Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time. The current review considers lipid metabolism and inflammation as well as nutritional and pharmacological agents affecting atherosclerosis, using the apo E knock out mouse model.
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Cite this article as:
Kolovou Genovefa, Anagnostopoulou Katherine, Mikhailidis P. Dimitri and Cokkinos V. Dennis, Apolipoprotein E Knockout Models, Current Pharmaceutical Design 2008; 14 (4) . https://dx.doi.org/10.2174/138161208783497769
DOI https://dx.doi.org/10.2174/138161208783497769 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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