摘要
简介:这项研究以社区为基础的墨西哥裔美国人样本中的血浆NfL与认知之间的关系为特征。 方法:544名参与者完成了一系列的神经心理学测试,并根据临床标准进行了诊断。 使用Simoa测定NfL。 跨组和测试的NfL水平进行了分析。 结果:正常和受损组之间存在NfL差异,这与整体认知,处理速度,执行功能和一系列学习任务相关,对所有诊断组均具有明显的负面影响。 NfL对正常和MCI组的处理速度,注意力,执行功能以及延迟记忆和识别记忆均具有负面影响。 结论:这项研究支持血浆NfL作为墨西哥裔美国人与神经退行性过程相关的认知障碍的标志物,并且可能是那些具有正常认知能力并有发展为MCI风险的人的早期认知变化的标志物。
关键词: 神经丝轻,墨西哥裔美国人,认知过程,正常认知,MCI,痴呆。
Current Alzheimer Research
Title:Relationship of Neurofilament Light (NfL) and Cognitive Performance in a Sample of Mexican Americans with Normal Cognition, Mild Cognitive Impairment and Dementia
Volume: 17 Issue: 13
关键词: 神经丝轻,墨西哥裔美国人,认知过程,正常认知,MCI,痴呆。
摘要:
Introduction: This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans.
Methods: 544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed.
Results: Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups.
Conclusion: The research supports plasma NfL as a marker of cognitive impairment related to neurodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.
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Cite this article as:
Relationship of Neurofilament Light (NfL) and Cognitive Performance in a Sample of Mexican Americans with Normal Cognition, Mild Cognitive Impairment and Dementia, Current Alzheimer Research 2020; 17 (13) . https://dx.doi.org/10.2174/1567205018666210219105949
DOI https://dx.doi.org/10.2174/1567205018666210219105949 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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