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The Natural Products Journal

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ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

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Research Article

Galanthum nivalis Extract is Neurologically Active and Improves Anxiety and Social Interactions in Mesocricetus auratus

Author(s): Heather A. Kip, Maya Kuro, Steven Hami, Terry Nugget and Evan R. Montre*

Volume 9, Issue 2, 2019

Page: [133 - 137] Pages: 5

DOI: 10.2174/2210315508666180515100620

Price: $65

Abstract

Background: Galanthum nivalis has been used throughout history for its medicinal properties. Although traditionally used as an antidote to poison, G. nivalis has also recently been found to have effects in neurological conditions such as Alzheimer’s Disease and mild cognitive impairment. Recent studies also suggest that it may have neurological activity that may be beneficial for psychiatric and neurological disorders like anxiety.

Objective: This study aimed to assess the neurological activity of G. nivalis extract using a behavioral test of anxiety-like behavior in Syrian hamsters.

Methods: G. nivalis extract was administered daily to hamsters while undergoing a semi-naturalistic version of the open field test to assess anxiety. Hamsters were video recorded during their natural active times beginning an hour before and ending an hour after lights-on and lights-off. Free roaming behaviors were scored in a 2 x 4 m open pen with enrichment objects for hamsters to interact with. After 10 days, hamsters were subjected to a social interaction test with a novel conspecific.

Results: Hamsters receiving G. nivalis extract showed increased time that was spent free-roaming and a greater proportion of that time was spent moving. They also spent more time interacting with enrichment objects in the open pen. The social interaction test showed that hamsters receiving G. nivalis extract spent more time playing with a novel conspecific.

Conclusion: G. nivalis extract is a neurologically active natural product with behaviorally relevant effects. It improved anxiety-like behavior in hamsters, as evidenced by increased time free roaming, moving, and interacting with objects, while improving social interactions.

Keywords: Galanthum nivalis, Mesocricetus auratus, anxiety, free-roam assay, social interaction, neurological activity.

Graphical Abstract

[1]
Plaitakis, A.; Duvoisin, R.C. Homer’s moly identified as Galanthus nivalis L.: physiologic antidote to stramonium poisoning. Clin. Neuropharmacol., 1983, 6(1), 1-5.
[2]
Hsieh, L.E.; Lin, C.N.; Su, B.L.; Jan, T.R.; Chen, C.M.; Wang, C.H.; Lin, D.S.; Lin, C.T.; Chueh, L.L. Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus. Antiviral Res., 2010, 88(1), 25-30.
[3]
Heinrich, M. Galanthamine from Galanthus and other Amaryllidaceae-chemistry and biology based on traditional use. Alkaloids Chem. Biol., 2010, 68, 157-165.
[4]
Tsvetkova, D.; Obreshkova, D.; Zheleva-Dimitrova, D.; Saso, L. Antioxidant activity of galantamine and some of its derivatives. Curr. Med. Chem., 2013, 20(36), 4595-4608.
[5]
Loy, C.; Schneider, L. Galantamine for Alzheimer’s disease and mild cognitive impairment. Cochrane Database Syst. Rev., 2006, 1.
[6]
Song, J.; Ahn, I.S.; Kang, H.S.; Myung, W.; Lee, Y.; Woo, S.Y.; Ku, H.M.; Hwang, T.Y.; Carroll, B.J.; Kim, D.K. Cognitive subdomain responses to galantamine in Alzheimer’s disease. J. Nerv. Ment. Dis., 2014, 202(3), 253-259.
[7]
Richarz, U.; Gaudig, M.; Rettig, K.; Schauble, B. Galantamine treatment in outpatients with mild Alzheimer’s disease. Acta Neurol. Scand., 2014, 129(6), 382-392.
[8]
Ghaleiha, A.; Ghyasvand, M.; Mohammadi, M.R.; Farokhnia, M.; Yadegari, N.; Tabrizi, M.; Hajiaghaee, R.; Yekehtaz, H.; Akhondzadeh, S. Galantamine efficacy and tolerability as an augmentative therapy in autistic children: A randomized, double-blind, placebo-controlled trial. J. Psychopharmacol. (Oxford, England), 2014, 28(7), 677-685.
[9]
Koseki, T.; Mouri, A.; Suzuki, S.; Nakajima, A.; Mamiya, T.; Yan, Y.; Nabeshima, T. Galantamine attenuates reinstatement of cue-induced methamphetamine-seeking behavior in mice. Addict. Biol., 2014, 19(1), 1-4.
[10]
Izzo, A.A.; Hoon‐Kim, S.; Radhakrishnan, R.; Williamson, E.M. A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies. Phytother. Res., 2016, 30(5), 691-700.
[11]
Poulsen, M.; Kroghsbo, S.; Schroder, M.; Wilcks, A.; Jacobsen, H.; Miller, A.; Frenzel, T.; Danier, J.; Rychlik, M.; Shu, Q.; Emami, K.; Sudhakar, D.; Gatehouse, A.; Engel, K.H.; Knudsen, I. A 90-day safety study in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA). Food Chem. Toxicol., 2007, 45(3), 350-363.
[12]
Ewen, S.W.; Pusztai, A. Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine. Lancet, 1999, 354(9187), 1353-1354.
[13]
Combs, H.; Markman, J. Anxiety disorders in primary care. Med. Clin. North Am., 2014, 98(5), 1007-1023.
[14]
Wazea, S.A.; Wadie, W.; Bahgat, A.K.; El-Abhar, H.S. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-kappaB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Sci. Rep., 2018, 8(1), 5110.
[15]
Picciotto, M.R.; Lewis, A.S.; van Schalkwyk, G.I.; Mineur, Y.S. Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states. Neuropharmacology, 2015. 96(Pt B), 235-243.
[16]
Stanford, S.C. Open fields (unlike wheels) can be any shape but still miss the target. J. Psychopharmacol., 2007, 21(2), 144.
[17]
Stanford, S.C. The Open Field Test: reinventing the wheel. J. Psychopharmacol., 2007, 21(2), 134-135.
[18]
Walsh, R.N.; Cummins, R.A. The Open-Field Test: A critical review. Psychol. Bull., 1976, 83(3), 482-504.
[19]
Makowska, I.J.; Weary, D.M. The importance of burrowing, climbing and standing upright for laboratory rats. R. Soc. Open Sci., 2016, 3(6), 160136.
[20]
Makowska, I.J.; Weary, D.M. Differences in Anticipatory behaviour between rats (Rattus norvegicus) housed in standard versus semi-naturalistic laboratory environments. PLoS One, 2016, 11(1), e0147595.
[21]
Bokov, D.O.; Samylina, I.A. Comparison of the chemical compositions of Galanthus woronowii losinsk. and Galanthus nivalis l. Homeopathic mother tinctures by gas chromatography with mass-selective detection. Pharm. Chem. J., 2017, 50(10), 659-667.
[22]
Sarikaya, B.B.; Somer, N.U.; Kaya, G.I.; Onur, M.A.; Bastida, J.; Berkov, S. GC-MS investigation and acetylcholinesterase inhibitory activity of Galanthus rizehensis. Zeitschrift fur Naturforschung. C. J. Biosci., 2013, 68(3-4), 118-124.
[23]
Fernandes, S.S.; Koth, A.P.; Parfitt, G.M.; Cordeiro, M.F.; Peixoto, C.S.; Soubhia, A.; Moreira, F.P.; Wiener, C.D.; Oses, J.P.; Kaszubowski, E.; Barros, D.M. Enhanced cholinergic-tone during the stress induce a depressive-like state in mice. Behav. Brain Res., 2018, 347, 17-25.
[24]
Kroes, R.A.; Burgdorf, J.; Otto, N.J.; Panksepp, J.; Moskal, J.R. Social defeat, a paradigm of depression in rats that elicits 22-kHz vocalizations, preferentially activates the cholinergic signaling pathway in the periaqueductal gray. Behav. Brain Res., 2007, 182(2), 290-300.
[25]
Leng, A.; Feldon, J.; Ferger, B. Long-term social isolation and medial prefrontal cortex: Dopaminergic and cholinergic neurotransmission. Pharmacol. Biochem. Behav., 2004, 77(2), 371-379.
[26]
Fang, L.; Fang, X.; Gou, S.; Lupp, A.; Lenhardt, I.; Sun, Y.; Huang, Z.; Chen, Y.; Zhang, Y.; Fleck, C. Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents. Eur. J. Med. Chem., 2014, 76, 376-386.

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