A Case-Control Study Investigating the Effect of MTHFR C677T Variant on Performance of Elite Athletes

Title:A Case-Control Study Investigating the Effect of MTHFR C677T Variant on Performance of Elite Athletes

Volume: 21 Issue: 9

Author(s): Ayse F. Nursal*, Serbulent Yigit, Husniye Rustemoglu and Abdullah Cenikli

Affiliation:

• Department of Medical Genetics, Faculty of Medicine, Hitit University, Corum,Turkey

Keywords: Sport performance, MTHFR, C677T, variant, sedentary, homocysteine (Hcy).

Abstract:

Objective: Increased level of plasma homocysteine (Hcy) is a potential risk factor for several multi-system diseases. The Methylenetetrahydrofolate reductase (MTHFR) gene C677T variant has been established as an important genetic determinant of hyperhomocysteinemia. There are conflicting reports about the effects of physical activity on plasma Hcy. Therefore, the main aim of this study was to investigate whether the MTHFR C677T variant affects elite athletic performance.

Methods: This study was carried out on 214 individuals (114 elite athletes and 100 sedentary controls). Genotyping was performed using PCR- RFLP method. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association.

Results: There was a significant difference between the athletes and the control group in genotype distribution and allele frequency of the MTHFR C677T variant. MTHFR C677T CC genotype and C allele were more prevalent in elite athletes than those in the sedentary controls (p =0.007, OR: 2.16, 95%:1.26-3.70; p=0.009, OR: 1.84, 95%:1.18-2.89, respectively). The control group had a higher MTHFR C677T CT genotype than the athletes (p=0.019, OR: 0.51, 95%:0.30-0.88). There was no deviation from HWE for the MTHFR C677T variant in the groups.

Conclusion: Our findings support that there is an association between the MTHFR C677T C allele and athletic performance among the elite Turkish athletes.

Cite this article as:

Nursal F. Ayse *, Yigit Serbulent , Rustemoglu Husniye and Cenikli Abdullah , A Case-Control Study Investigating the Effect of MTHFR C677T Variant on Performance of Elite Athletes, Endocrine, Metabolic & Immune Disorders - Drug Targets 2021; 21 (9) . https://dx.doi.org/10.2174/1568026620666201022144819