Abstract
Coronavirus disease 2019 (COVID-19) is an acute respiratory tract infection causing a pandemic that emerged in 2019 initially in China involving 13.8% cases with severe, and 6.1% with critical course and later throughout the globe. Vaccines or antiviral medications are yet to be used to prevent or treat infections of Human Coronavirus (HCoV). The much-discovered HCoV found in 2003, SARSCOVID- 19, which caused respiratory syndrome, has special pathogenesis as it causes respiratory tract infection. The coronavirus spike protein's association with its host cell receptor complement is crucial in deciding the virus infectivity, tissue tropism and species variety. SARS, COVID-19, infects human cells by binding to angiotensin-converting enzyme 2 (ACE2) receptor and uses the TMPRSS2 cell protease to activate it. Lungs are most affected by COVID-19 as host cells are accessed by the virus through ACE2, which is most abundant in alveolar cells of the lungs. Special attention and efforts should be given in reducing transmission in vulnerable populations, including infants, health care providers and the elderly. COVID 19, is the main causative agent of potentially lethal disease and is of significant concern for global public health and in pandemics which was highlighted in this review.
Keywords: Coronavirus, COVID-19, ACE2, TMPRSS2, pandemic, antibody therapy.
Coronaviruses
Title:Impact and Inescapable Effects of Coronavirus: History to Modern Pandemic Episode
Volume: 2 Issue: 1
Author(s): Suman K. Ray, Yamini Meshram and Sukhes Mukherjee*
Affiliation:
- Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh-462020,India
Keywords: Coronavirus, COVID-19, ACE2, TMPRSS2, pandemic, antibody therapy.
Abstract: Coronavirus disease 2019 (COVID-19) is an acute respiratory tract infection causing a pandemic that emerged in 2019 initially in China involving 13.8% cases with severe, and 6.1% with critical course and later throughout the globe. Vaccines or antiviral medications are yet to be used to prevent or treat infections of Human Coronavirus (HCoV). The much-discovered HCoV found in 2003, SARSCOVID- 19, which caused respiratory syndrome, has special pathogenesis as it causes respiratory tract infection. The coronavirus spike protein's association with its host cell receptor complement is crucial in deciding the virus infectivity, tissue tropism and species variety. SARS, COVID-19, infects human cells by binding to angiotensin-converting enzyme 2 (ACE2) receptor and uses the TMPRSS2 cell protease to activate it. Lungs are most affected by COVID-19 as host cells are accessed by the virus through ACE2, which is most abundant in alveolar cells of the lungs. Special attention and efforts should be given in reducing transmission in vulnerable populations, including infants, health care providers and the elderly. COVID 19, is the main causative agent of potentially lethal disease and is of significant concern for global public health and in pandemics which was highlighted in this review.
Export Options
About this article
Cite this article as:
Ray K. Suman , Meshram Yamini and Mukherjee Sukhes *, Impact and Inescapable Effects of Coronavirus: History to Modern Pandemic Episode, Coronaviruses 2021; 2 (1) . https://dx.doi.org/10.2174/2666796701999200701123714
DOI https://dx.doi.org/10.2174/2666796701999200701123714 |
Print ISSN 2666-7967 |
Publisher Name Bentham Science Publisher |
Online ISSN 2666-7975 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Comparative Analysis of Protein Interfaces
Protein & Peptide Letters A Review on Coronavirus Disease- A Future Challenge for Mankind (Focusing on Indian Situation)
Coronaviruses The Rapidly Changing Composition of the Global Street Drug Supply and its Effects on High-risk Groups for COVID-19
Current Psychopharmacology SARS-CoV-2 Therapy: Old Drugs as New Interventions
Coronaviruses Catechin Derivatives as Inhibitor of COVID-19 Main Protease (Mpro): Molecular Docking Studies Unveil an Opportunity Against CORONA
Combinatorial Chemistry & High Throughput Screening The use of Pseudotyped Coronaviruses for the Screening of Entry Inhibitors: Green Tea Extract Inhibits the Entry of SARS-CoV-1, MERSCoV, and SARS-CoV-2 by Blocking Receptor-spike Interaction
Current Pharmaceutical Biotechnology Symptoms, Transmission, Prevention and Treatment of Pandemic Corona Virus: A Review
Coronaviruses Loneliness and Social Isolation: Determinants of Cardiovascular Outcomes
Current Cardiology Reviews The Immunomodulatory Effects of Physical Activity
Current Pharmaceutical Design COVID-19: An Opinion of Prevention and Dietary Based Management Hypothesis
Coronaviruses An Urgent Industrial Scheme Both for Total Synthesis, and for Pharmaceutical Analytical Analysis of Umifenovir as an Anti-viral API for Treatment of COVID-19
Combinatorial Chemistry & High Throughput Screening Rhinovirus-Associated Wheeze During Infancy and Asthma Development
Current Respiratory Medicine Reviews Flexibility as a Strategy in Nucleoside Antiviral Drug Design
Current Medicinal Chemistry Traditional Medicine - A Possible Stop Codon for COVID-19
Current Traditional Medicine Identification of Ligand-Binding Pockets in Proteins Using Residue Preference Methods
Protein & Peptide Letters Can Cannabinoids Suppress the Cytokines Cascade in Patients with Coronavirus Disease COVID-19? A Mini-Review
Coronaviruses Synthesis and Biological Evaluation of Some New N4-Aryl Substituted 5-Chloroisatin-3-thiosemicarbazones
Medicinal Chemistry Structure-Based Virtual Ligand Screening: Recent Success Stories
Combinatorial Chemistry & High Throughput Screening Caring for HIV-Infected Patients in the ICU in The Highly Active Antiretroviral Therapy Era
Current HIV Research Preliminary Identification of Hamamelitannin and Rosmarinic Acid as COVID-19 Inhibitors Based on Molecular Docking
Letters in Drug Design & Discovery