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General Review Article

内脏利什曼病(VL)的研究前景及潜在药物靶点

卷 21, 期 11, 2020

页: [1105 - 1129] 页: 25

弟呕挨: 10.2174/1389450121666200422083735

价格: $65

摘要

利什曼病是世界卫生组织/热带病研究组织(WHO/TDR)最重要疾病清单上的六个实体之一。它是继疟疾之后最流行、最致命的寄生虫病之一。VL是这种疾病的致命形式，特别是如果不治疗。目前可用来治疗VL的药物价格昂贵、有毒或不再有效，特别是在流行地区。目前，还没有开发出可以使人类免疫抵抗VL的疫苗。目前药物的主要问题是耐药性的发展及其副作用。因此，研究和设计比目前的化疗药物更有效、更低毒性的药物是迫切需要的。利什曼原虫的代谢途径涉及多种酶，这些酶对同属或锥虫都是独特的，这使它们成为药物开发非常合适、有吸引力和新颖的靶点。硫醇代谢途径是锥虫独特的重要途径之一，它参与维持氧化还原稳态以及保护巨噬细胞中的寄生虫免受氧化应激诱导的损伤。本文对几种途径、它们的主要酶以及寄生虫因耐药而发生的变化进行了讨论，以帮助我们了解最合适的药物靶点。详细讨论了硫醇代谢途径，证明该途径是VL中药物靶向的最佳选择。

关键词: 利什曼病、耐药、代谢过程、药物靶点、致命寄生虫病、锥虫

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