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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

氟西汀可预防中年APPswe / PSEN1dE9双转基因阿尔茨海默氏病小鼠的树突棘损失

卷 17, 期 1, 2020

页: [93 - 103] 页: 11

弟呕挨: 10.2174/1567205017666200213095419

价格: $65

摘要

背景：研究表明，阿尔茨海默氏病（AD）的认知障碍与树突棘丧失有关，尤其是在海马中。氟西汀（FLX）已被证明可以改善AD早期的认知，并与减少海马突触变性有关。然而，关于FLX是否在中晚期阶段影响AD的发病机理以及其作用是否与海马树突功能障碍的改善相关，人们所知甚少。以前，已经观察到FLX可以改善中年APP / PS1小鼠的空间学习能力。 目的：在本研究中，我们进一步表征了FLX对中年APP / PS1小鼠海马树突棘的影响。 结果：已经发现，FLX显着增加了海马齿状回（DG），CA1和CA2 / 3的树突棘数量。同时，FLX有效减弱了Ser396上tau的过度磷酸化，并提高了海马突触后密度95（PSD-95）和突触蛋白1（SYN-1）的蛋白水平。 结论：这些结果表明，FLX治疗的中年APP / PS1小鼠观察到的学习能力增强可能与FLX显着减轻海马树突状脊柱病理有关，并暗示FLX有望被探索为治疗AD的新策略在中后期。

关键词: 氟西汀，树突棘，海马，学习能力，阿尔茨海默氏病，神经退行性疾病。

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