A Review on Defects of Dendritic Cells in Common Variable Immunodeficiency

Title:A Review on Defects of Dendritic Cells in Common Variable Immunodeficiency

Volume: 17 Issue: 2

Author(s): Laleh Sharifi, Naeimeh Tavakolinia, Fatemeh Kiaee, Nima Rezaei, Monireh Mohsenzadegan, Gholamreza Azizi, Reza Yazdani, Mansoureh Shariat, Abbas Mirshafiey*Asghar Aghamohammadi*

Affiliation:

• Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran,Iran

• Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran,Iran

Keywords: Common variable immunodeficiency, dendritic cells, B-cell, T-cell, toll-like receptors, cytokines.

Abstract: Background and Objectives: Common variable immunodeficiency (CVID) is the most important primary disorder that is associated with clinical complications including recurrent infections, malignancy and autoimmune diseases. The genetic cause of CVID is mostly unknown and only a few genetic causes are identified. The various options are proposed for determining the etiology of CVID patients, such as T- and B-cell defects, Toll-like receptors (TLRs) impairments, altered cytokine production as well as blemished dendritic cells (DCs). The patients with CVID show a reduction in number and frequency of DCs in blood, an altered expression of cell surface molecules, and defective activation through toll-like receptors (TLRs). Also loss of IFNα has a critical role in B-cell impairments of CVID patients. The aim of this review is to collect under one umbrella, all the recent knowledge about DCs defects of CVID patients.

Cite this article as:

Sharifi Laleh , Tavakolinia Naeimeh , Kiaee Fatemeh, Rezaei Nima , Mohsenzadegan Monireh, Azizi Gholamreza , Yazdani Reza, Shariat Mansoureh , Mirshafiey Abbas *, Aghamohammadi Asghar *, A Review on Defects of Dendritic Cells in Common Variable Immunodeficiency, Endocrine, Metabolic & Immune Disorders - Drug Targets 2017; 17 (2) . https://dx.doi.org/10.2174/1871530317666170613125009