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Review Article

青蛙皮肤肽抗感染治疗的潜力：Esculentin-1a（1-21）NH2的病例。

卷 27, 期 9, 2020

页: [1405 - 1419] 页: 15

弟呕挨: 10.2174/0929867326666190722095408

价格: $65

摘要

抗菌肽（AMPs）是先天免疫的关键效应物，代表了开发新抗菌药物的有前途的分子。但是，为了实现这一目标，需要克服一些问题：（i）高浓度时的细胞毒性作用； （ii）生物稳定性差，并且（iii）难以到达目标位置。蛙皮是AMPs最丰富的天然仓库之一，多年来，已从中分离出许多肽，对其进行了表征和分类，包括temporins，brevinins，Nigrocins和esculentins几个家族。在这篇综述中，我们总结了属于esculentin-1家族的肽的分离/表征如何推动我们设计具有强大抗菌作用和免疫调节特性的类似物esculentin-1a（1-21）NH2。该肽具有广泛的活性，特别是针对机会性革兰氏阴性菌铜绿假单胞菌。我们描述了该肽的结构特征和体外/体内生物学特性，以及用于改善其生物学特性的策略。其中：（i）设计一种带有D氨基酸的非对映异构体，以减少该肽的细胞毒性并提高其半衰期； （ii）肽与金纳米颗粒的共价缀合或将其封装到聚（丙交酯-共-乙交酯）纳米颗粒中； （iii）将肽固定在生物医学装置（例如硅水凝胶隐形眼镜）上以获得能够减少微生物生长和附着的抗菌表面。总结迄今为止所取得的最佳结果，本综述追溯了导致这些蛙皮AMP朝着基于肽的药物走向临床用途的所有步骤。

关键词: 抗菌肽，铜绿假单胞菌，先天免疫，金纳米颗粒，隐形眼镜，D-氨基酸，伤口愈合。

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