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Review Article

在神经系统癌症中针对长非编码RNA的靶向：在预后，诊断和治疗中的新见解

卷 26, 期 30, 2019

页: [5649 - 5663] 页: 15

弟呕挨: 10.2174/0929867325666180831170227

价格: $65

摘要

长的非编码RNA（lncRNA）构成了最广泛多样的细胞转录物之一，在许多生物学过程中作为调节分子发挥着关键作用。尽管lncRNAs的生物学是一个新兴的研究领域，但一些研究已经表明，lncRNAs表达的改变与癌症在不同器官和组织（包括中枢和周围神经系统）中的发生和发展有关。在这篇综述中，我们总结了lncRNA在神经系统恶性肿瘤（例如神经胶质瘤和神经母细胞瘤）中的致癌作用和抑癌作用，重点是它们与DNA，其他RNA和蛋白质分子的功能性相互作用。我们进一步讨论了lncRNAs作为生物标志物在诊断，预后和肿瘤治疗中的潜在用途。对神经系统恶性肿瘤和lncRNA之间的功能关联的深入了解可能为开发有前途的抗癌治疗工具提供新的观点。

关键词: 胶质母细胞瘤，神经母细胞瘤，HOTAIR，XIST，MALAT1，MEG3，I-BET，循环lncRNA。

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