Modified Envelope Glycoproteins to Retarget Retroviral Vectors

Title: Modified Envelope Glycoproteins to Retarget Retroviral Vectors

Volume: 3 Issue: 5

Author(s): Catherine Haynes, Otto Erlwein and Barbara S. Schnierle

Affiliation:

Keywords: murine leukemia virus, targeting, vector, envelope, virus entry, host range

Abstract: A conceptual breakthrough in gene therapy would be gene transfer vector that could be systemically applied, allowing targeted gene transfer into a predetermined cell type. The host range of a retroviral vector is determined by the interaction of the viral envelope glycoprotein (Env) and the retrovirus receptor on the surface of the host cell. In this review, we describe the current efforts to engineer targeted envelope glycoproteins, which can be incorporated into retroviral particles and are capable of delivering genes in a highly specific manner.

Cite this article as:

Haynes Catherine, Erlwein Otto and Schnierle S. Barbara, Modified Envelope Glycoproteins to Retarget Retroviral Vectors, Current Gene Therapy 2003; 3 (5) . https://dx.doi.org/10.2174/1566523034578267