Glioblastoma Multiforme，诊断和治疗；近期文献综述

Title:Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review

Volume: 24 Issue: 27

关键词: 生物制剂、化疗、多形性胶质母细胞瘤，免疫治疗，放射治疗，免疫接种。

摘要: Background: Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, with an incidence of 3.19 cases per 100,000 person years and remarkably poor prognosis showing a 5-year survival rate of 4-5%, and only a 26-33% survival rate at 2 years in clinical trials.

Objective: In this paper, we review the different types of treatment modalities based on the relevant databases. Methods of diagnosis will be described briefly.

Method: Systemic compilation of the relevant literature.

Results & Conclusion: Today's treatments cannot cure GBM patients but only extend their overall survival. The use of chemoradiation, immunotherapy, and radio sensitizers as an adjuvant therapy cannot reduce the high rates of recurrence within a few months after treatment. Radiotherapy will remain the backbone of the treatment but new treatment modalities must be developed.

Cite this article as:

Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review, Current Medicinal Chemistry 2017; 24 (27) . https://dx.doi.org/10.2174/0929867324666170516123206