Abstract
The interaction between cancer cells and their microenvironment is an indispensable link in cancer progression that occurs on the interfaces between them and presents typical biointerfacial behavior. Recently, the cancer cell/microenvironment interface has begun to attract more attention because of its fundamental roles in cancer growth and metastasis, which is promising for the efficacy of anti-cancer drugs and other important effects. In this review, we focused on mechanical coupling of the biointerfaces and their application in cancer early diagnosis, the pharmacology of anticancer agents and the design of the anticancer drug carriers. Newly developed strategies for cancer therapy based on mechanical coupling, such as correcting cell mechanics defects, tunable rigidity for drug delivery and topography-coupled-mechanical drug design, and drug screening, provide a proof of concept that cell mechanics offer a rich drug target space, allowing for the possible corrective modulation of tumor cell behavior. Biomechanopharmacology is therefore important to recognize the biomechanical factors and to control them not only for improvement in our knowledge of cancer but also for the development of new drugs and new uses of old drugs.
Keywords: Cancer cell/microenvironment interface, Mechanical coupling, Cancer drug therapy, Drug screening, Biomechanopharmacology.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Micro-/Nano-Scale Biointerfaces, Mechanical Coupling and Cancer Therapy
Volume: 17 Issue: 16
Author(s): Xiang Li, Cuiying Liu, Peipei Chen*Dong Han
Affiliation:
- CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190,China
Keywords: Cancer cell/microenvironment interface, Mechanical coupling, Cancer drug therapy, Drug screening, Biomechanopharmacology.
Abstract: The interaction between cancer cells and their microenvironment is an indispensable link in cancer progression that occurs on the interfaces between them and presents typical biointerfacial behavior. Recently, the cancer cell/microenvironment interface has begun to attract more attention because of its fundamental roles in cancer growth and metastasis, which is promising for the efficacy of anti-cancer drugs and other important effects. In this review, we focused on mechanical coupling of the biointerfaces and their application in cancer early diagnosis, the pharmacology of anticancer agents and the design of the anticancer drug carriers. Newly developed strategies for cancer therapy based on mechanical coupling, such as correcting cell mechanics defects, tunable rigidity for drug delivery and topography-coupled-mechanical drug design, and drug screening, provide a proof of concept that cell mechanics offer a rich drug target space, allowing for the possible corrective modulation of tumor cell behavior. Biomechanopharmacology is therefore important to recognize the biomechanical factors and to control them not only for improvement in our knowledge of cancer but also for the development of new drugs and new uses of old drugs.
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Cite this article as:
Li Xiang, Liu Cuiying, Chen Peipei*, Han Dong, Micro-/Nano-Scale Biointerfaces, Mechanical Coupling and Cancer Therapy, Current Topics in Medicinal Chemistry 2017; 17 (16) . https://dx.doi.org/10.2174/1568026617666161122120854
DOI https://dx.doi.org/10.2174/1568026617666161122120854 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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