Abstract
With the progress of nanotechnology, the treatment of cancer by photothermal therapy (PTT) and photodynamic therapy (PDT) using theranostic nanomaterials based on iron oxide (Fe3O4) and gold (Au) nanoparticles (NPs) has received much attention in recent years. The Fe3O4 NPs have been used as imaging-guided PTT of cancer due to their high relaxivity, excellent contrast enhancement, and less toxicity. The Au NPs have been widely employed as a contrast agent for CT imaging of different biological systems due to their enhanced X-ray attenuation property. Due to the strong surface plasmon resonance (SPR) absorption intensity in near-infrared (NIR) region, Au NPs have been considered for imaging-guided PTT of cancer. Since the photosensitizer, which plays an important role in PDT of cancer, can be efficiently conjugated with Fe3O4 and Au NPs, these NPs have also been considered for imaging-guided PDT of cancer. It has been found that both Fe3O4 and Au NPs allow passive targeting of tumors through enhanced permeability and retention (EPR) effect to improve the treatment efficacy in PTT and PDT. The present review focuses on the recent developments of Fe3O4 and Au-based NPs as theranostics for imaging-guided PTT and PDT of cancer.
Keywords: Theranostics, Tumor, Iron oxide, Gold, Photothermal therapy, Photodynamic therapy.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Theranostics Based on Iron Oxide and Gold Nanoparticles for Imaging- Guided Photothermal and Photodynamic Therapy of Cancer
Volume: 17 Issue: 16
Author(s): S. Rajkumar and M. Prabaharan*
Affiliation:
- Department of Chemistry, Hindustan Institute of Technology and Science, No.1, Rajiv Gandhi Salai, Padur, Chennai 603 103,0
Keywords: Theranostics, Tumor, Iron oxide, Gold, Photothermal therapy, Photodynamic therapy.
Abstract: With the progress of nanotechnology, the treatment of cancer by photothermal therapy (PTT) and photodynamic therapy (PDT) using theranostic nanomaterials based on iron oxide (Fe3O4) and gold (Au) nanoparticles (NPs) has received much attention in recent years. The Fe3O4 NPs have been used as imaging-guided PTT of cancer due to their high relaxivity, excellent contrast enhancement, and less toxicity. The Au NPs have been widely employed as a contrast agent for CT imaging of different biological systems due to their enhanced X-ray attenuation property. Due to the strong surface plasmon resonance (SPR) absorption intensity in near-infrared (NIR) region, Au NPs have been considered for imaging-guided PTT of cancer. Since the photosensitizer, which plays an important role in PDT of cancer, can be efficiently conjugated with Fe3O4 and Au NPs, these NPs have also been considered for imaging-guided PDT of cancer. It has been found that both Fe3O4 and Au NPs allow passive targeting of tumors through enhanced permeability and retention (EPR) effect to improve the treatment efficacy in PTT and PDT. The present review focuses on the recent developments of Fe3O4 and Au-based NPs as theranostics for imaging-guided PTT and PDT of cancer.
Export Options
About this article
Cite this article as:
Rajkumar S. and Prabaharan M.*, Theranostics Based on Iron Oxide and Gold Nanoparticles for Imaging- Guided Photothermal and Photodynamic Therapy of Cancer, Current Topics in Medicinal Chemistry 2017; 17 (16) . https://dx.doi.org/10.2174/1568026617666161122120537
DOI https://dx.doi.org/10.2174/1568026617666161122120537 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Medicinal Chemistry Advancement in Life-Threatening Diseases
The current issue will highlight concise reports that specify ground-breaking insights, including the novel discovery of drug targets and their action mechanism or drugs of novel classes. These are projected to encourage medicinal chemistry future efforts to address the most challenging medical needs. The current issue highlights further efforts to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Review on the Synthesis and Anti-cancer Activity of 2-substituted Quinolines
Anti-Cancer Agents in Medicinal Chemistry Toll-Like Receptors: Cost or Benefit for Cancer?
Current Pharmaceutical Design Synthesis, Characterization, Biological Evaluation and Molecular Docking Studies of New Oxoacrylate and Acetamide on HeLa Cancer Cell Lines
Current Computer-Aided Drug Design Modifications of Isoalantolactone Leading to Effective Anti-bacterial and Anti-viral Compounds
Letters in Drug Design & Discovery Jaridonin, a Novel Ent-Kaurene Diterpenoid from Isodon rubescens, Inducing Apoptosis via Production of Reactive Oxygen Species in Esophageal Cancer Cells
Current Cancer Drug Targets An Efficient Approach for Diagnosis System of Cervical Cancer Using Image Fusion to Prevent Earlier Death in Women
Current Medical Imaging Anticancer Perspectives on the Fungal-Derived Polyphenolic Hispolon
Anti-Cancer Agents in Medicinal Chemistry Sodium Selenite Decreased HDAC Activity, Cell Proliferation and Induced Apoptosis in Three Human Glioblastoma Cells
Anti-Cancer Agents in Medicinal Chemistry CD44 and EpCAM: Cancer-Initiating Cell Markers
Current Molecular Medicine The Cyclin-Dependent Kinase Inhibitor p21CDKN1A as a Target of Anti-Cancer Drugs
Current Cancer Drug Targets Application of Quantum Dots in Drug Delivery
Nanoscience & Nanotechnology-Asia Synthesis of pyridyl benzimidazoles encompassing 4-thiazolidinone derivatives as potential antimicrobial agents
Letters in Drug Design & Discovery Potential MicroRNA Targets for Cancer Chemotherapy
Current Medicinal Chemistry Induced Fit Docking and Automated QSAR Studies Reveal the ER-α Inhibitory Activity of <i>Cannabis sativa</i> in Breast Cancer
Recent Patents on Anti-Cancer Drug Discovery Cervical Cancer Prevention: More than Just a Pap in a Diverse Urban Community
Current Women`s Health Reviews Emerging Roles of MicroRNA-22 in Human Disease and Normal Physiology
Current Molecular Medicine Inhibitors of HIV-1 Protease: Current State of the Art 10 Years After their Introduction. From Antiretroviral Drugs to Antifungal, Antibacterial and Antitumor Agents Based on Aspartic Protease Inhibitors
Current Medicinal Chemistry The Synthesis, Structure and Activity Evaluation of Secnidazole Derivatives as Helicobacter pylori Urease Inhibitors
Current Bioactive Compounds Immunotherapeutic Approaches in MS: Update on Pathophysiology and Emerging Agents or Strategies 2006
Endocrine, Metabolic & Immune Disorders - Drug Targets Artemisia Species as a New Candidate for Diabetes Therapy: A Comprehensive Review
Current Molecular Medicine